摘要
目的探究垂体后叶素结合卡前列素氨丁三醇治疗胎盘早剥产后出血患者的效果。方法选取2019年1月至2020年12月我院收治的80例胎盘早剥产后出血患者作为研究对象,根据临床编号奇偶性将其分为对照组与观察组,各40例。对照组给予常规缩宫素联合米索前列醇治疗,观察组给予垂体后叶素结合卡前列素氨丁三醇治疗。比较两组的治疗效果。结果观察组的产后30min及2、12、24h出血量少于对照组,完全止血时间短于对照组,产后大出血率低于对照组(P<0.05)。治疗后,观察组的凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)短于对照组,纤维蛋白原(Fib)、D-二聚体(D-D)水平高于对照组(P<0.05)。观察组的不良事件总发生率低于对照组(P<0.05)。观察组的治疗总有效率高于对照组(P<0.05)。结论垂体后叶素结合卡前列素氨丁三醇治疗胎盘早剥产后出血患者可减少失血量,缩短止血时间,降低不良事件发生率,提高治疗效果。
Objective To investigate the effect of pituitrin combined with carboprost tromethamine in the treatment of patients with placental abruption postpartum hemorrhage.Methods Eighty patients with placental abruption postpartum hemorrhage admitted in our hospital from January 2019 to December 2020 were selected as the research objects and divided into control group and observation group according to clinical number parity,with 40 cases in each group.The control group was treated with conventional oxytocin combined with misoprostol,and the observation group was treated with pituitrin combined with carboprost tromethamine.The therapeutic effects of the two groups were compared.Results The blood loss at 30min,2,12 and 24h postpartum in the observation group was less than that in the control group,the complete hemostatic time was shorter than that in the control group,and the postpartum massive bleeding rate was lower than that in the control group(P<0.05).After treatment,the prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)in the observation group were shorter than those in the control group,and the fibrinogen(Fib)and D-dimer(D-D)levels were higher than those in the control group(P<0.05).The total incidence of adverse events in the observation group was lower than that in the control group(P<0.05).The total effective rate of treatment of the observation group was higher than that of the control group(P<0.05).Conclusion Pituitrin combined with carboprost tromethamine in the treatment of patients with placental abruption postpartum hemorrhage can reduce blood loss,shorten the hemostasis time,reduce the incidence of adverse events,and improve the therapeutic effect.
作者
崔化云
陈霞
CUI Huayun;CHEN Xia(Obstetrics Department,Women and Enfants Care Hospital of Dengzhou,Nanyang 474150;Obstetrics Department,Nanyang Central Hospital,Nanyang 474183,China)
出处
《临床医学研究与实践》
2023年第4期120-122,共3页
Clinical Research and Practice
