摘要
Hydrogen sulfide(H_(2)S)has been reported as an endogenous gasotransmitter that contributes to the modulation of a myriad of biological signalling pathways,which includes maintaining homeostasis in living organisms at physiological concentrations,controlling protein sulfhydration and persulfidation for signalling processes,mediating neurodegeneration,and regulating inflammation and innate immunity,etc.As a result,researchers are actively exploring effective approaches to evaluate the properties and the distribution of H_(2)S in vivo.Furthermore,the regulation of the physiological conditions of H_(2)S in vivo introduces the opportunity to further study the molecular mechanisms by which H_(2)S regulates cellular functions.In recent years,many H_(2)S-releasing compounds and biomaterials that can deliver H_(2)S to various body systems have been developed to provide sustained and stable H_(2)S delivery.Additionally,various designs of these H_(2)S-releasing biomaterials have been proposed to aid in the normal conduction of physiological processes,such as cardioprotection and wound healing,by modulating different signalling pathways and cell functionalities.Using biomaterials as a platform to control the delivery of H_(2)S introduces the opportunity to fine tune the physiological concentration of H_(2)S in vivo,a key to many therapeutic applications.In this review,we highlight recent research works concerning the development and application of H_(2)S-releasing biomaterials with a special emphasis to different release triggering conditions in in vivo studies.We believe that the further exploration of the molecular mechanisms underlying H_(2)S donors and their function when incorporated with various biomaterials will potentially help us understand the pathophysiological mechanisms of different diseases and assist the development of H_(2)S-based therapies.
基金
This work was partially supported by University of South Carolina and Central South University in China。
