摘要
感染后肠易激综合征是肠易激综合征的一种类型,即以前无IBS症状的人群在感染性胃肠炎发作后随即发生的肠易激综合征。肠道免疫活化、持续低度炎症和内脏高敏感是感染后肠易激综合征主要的病理特征;而在肝郁脾虚的基础上存在邪气未尽、伏藏于内的正邪交争状态是其中医病机特点,其中湿邪是导致其反复发作,难以速去的关键。该文从肠道免疫活化介导内脏高敏感的角度探讨其核心病机肝郁脾虚夹湿证病理机制的研究思路,以期为后续的进一步深入研究提供参考。
Post-infectious irritable bowel syndrome is a type of irritable bowel syndrome that occurs immediately after the onset of infectious gastroenteritis in people who previously had no symptoms of irritable bowel syndrome.Intestinal immune activation,persistent low-grade inflammation and visceral hypersensitivity are the main pathological features of post-infectious irritable bowel syndrome.On the basis of liver stagnation and spleen deficiency,there is a state of conflict between healthy Qi and pathogenic evils,which is the characteristic of Traditional Chinese Medicine pathogenesis.Meanwhile,damp evil is the key to its repeated attacks and difficult to go away quickly.Therefore,from the perspective of intestinal immune activation mediating visceral hypersensitivity,this paper discussed the research ideas on the pathological mechanism of the syndrome of dampness with depression of liver and deficiency of spleen,which is the core pathogenesis,in order to provide reference for further research.
作者
秦书敏
杨元明
吴皓萌
郑欢
黄绍刚
QIN Shumin;YANG Yuanming;WU Haomeng;ZHENG Huan;HUANG Shaogang(Department of Gastroenterology,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,510006,China;Guangzhou University of Chinese Medicine)
出处
《中国中西医结合消化杂志》
CAS
2023年第1期61-64,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金(No:81904148,No:81703992,No:81974563)
中国博士后科学基金项目(No:2018M640222)
北京市自然科学基金资助项目(No:7192184)
广东省普通高校青年创新人才项目(No:2019KQNCX023)
广东省医学科学技术研究基金项目(No:A2020181,No:A2017394)
广东省中医药局中医药科研项目(No:20192024)
广州市科技计划项目(No:20210201040527)
广东省中医院中医药科学技术研究专项(No:YN2016QJ14)。
关键词
感染后肠易激综合征
内脏高敏感
肠道免疫
肝郁脾虚夹湿证
post-infectious irritable bowel syndrome
visceral hypersensitivity
intestinal immunity
liver stagnation and spleen deficiency with dampness syndrome
