摘要
脓毒症本质是一种全身性炎症反应综合征,病情变化复杂,毒热内蕴是脓毒症的重要发病基础,也是向重症感染转向的内因。毒热致病临床上运用黄连解毒汤治疗脓毒症疗效确切,但作用机制难以阐明。中医复方疗效显著,但多成分、多通路、多靶点治疗疾病的机制仍难以阐明。本文探讨黄连解毒汤对脓毒症治疗机理,以期为黄连解毒汤治疗脓毒症作用研究提供理论基础。
Sepsis is essentially a systemic inflammatory response syndrome with complex changes,and the stagnation of toxin-heat is a major pathogenetic basis of sepsis and an internal cause of the progression to severe cases.Huanglian Jiedu Decoction is effective for sepsis in clinical practice,the mechanism of which remains to be deciphered because of the multiple components,targets,and pathways.In this paper,we investigate the therapeutic mechanism of Huanglian Jiedu Decoction for sepsis,aiming to provide a theoretical basis for the relevant research.
作者
江桂通
王腊
田维毅
JIANG Guitong;WANG La;TIAN Weiyi(Guizhou University of Traditional Chinese Medicine,Guiyang 550000,China;Department of Traditional Chinese Medicine,Cengong County People's Hospital,Kaili 556000,China)
出处
《基层中医药》
2022年第12期38-43,共6页
Basic Traditional Chinese Medicine
基金
国家自然科学基金(81960796)
贵州中医药大学博士启动基金([2019]23号)。
关键词
脓毒症
毒热论
黄连解毒汤
sepsis
toxin-heat theory
Huanglian Jiedu Decoction
