摘要
心血管疾病一直是威胁人类生命健康的一大类疾病,最新研究显示,一类内源性非编码RNA(约22 NT)在心血管疾病发生与发展中的作用不容忽视。microRNA-92a(miR-92a)是microRNAs家族中的重要成员,其在动脉粥样硬化、急性冠脉综合征、心肌梗死等心血管疾病的病理生理过程中扮演着重要角色。大量研究表明,组织细胞或循环中不同表达程度的miR-92a通过调节相关蛋白的表达及信号通路参与各类心血管疾病的发生和发展。文章就miR-92a在心血管疾病中的作用作一综述。
Cardiovascular disease has always been a major disease threatening human life and health.According to the latest research,a class of endogenous non coding RNA(about 22 NT)plays an important role in the occurrence and development of cardiovascular diseases.MicroRNA-92a(miR-92a)is an important member of the microRNAs family.It plays an important role in the pathophysiology of cardiovascular diseases such as atherosclerosis,acute coronary syndrome,myocardial infarction and so on.A large number of studies have shown that miR-92a with different expression levels in tissue cells or circulation participates in the occurrence and development of various cardiovascular diseases by regulating the expression of related proteins and signaling pathways.This review summarizes the role of miR-92a in cardiovascular disease.
作者
曹伟丽
贾丹
黄立娟
Cao Weili;Jia Dan;Huang Lijuan(Laboratory Department,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)
出处
《国际免疫学杂志》
CAS
2022年第5期548-552,共5页
International Journal of Immunology
