摘要
丁苯酞(NBP)为多靶点抗脑缺血药物,具有保护线粒体、抗氧化、抑制神经炎症等作用。NBP主要用于治疗轻、中度急性缺血性脑卒中,可改善缺血性脑卒中患者的神经功能、认知功能和生活能力,疗效确切且安全性好。近年来大量研究显示,NBP的作用靶点与帕金森病(PD)的主要病理途径吻合,能显著改善患者临床症状和生命体征,治疗PD具有巨大潜力。该文对NBP治疗PD的临床前研究及临床试验研究进行总结,以期为治疗PD提供新思路。
N-Butylphthalide(NBP)is a multi-targeted anti-cerebral ischemia drug,which protects mitochondria,provides anti-oxidation,and inhibits neuroinflammation.NBP is mainly used for treating mild to moderate acute ischemic stroke,which can improve the neurological function,cognitive function,and living ability of patients with ischemic stroke,with definite curative effect and good safety.In recent years,many studies have shown that the target of NBP is consistent with the main pathological pathway of Parkinson's disease(PD),which can significantly improve the clinical symptoms and vital signs of patients,and has great potential for the treatment of PD.Therefore,this paper summarizes the preclinical studies and clinical trial studies of NBP for the treatment of PD to provide new ideas for the treatment of PD.
作者
胡琪
陶雪
蒋敏
刘雨蒙
郭文玫
龙恩武
边原
童荣生
HU Qi;TAO Xue;JIANG Min;LIU Yumeng;GUO Wenmei;LONG Enwu;BIAN Yuan;TONG Rongsheng(School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China;School of Pharmacy,Southwest Medical University,Luzhou 646000,China;Chengdu Women and Children's Central Hospital,the Affiliated Hospital of Medical College,University of Electronic Science and Technology of China,Chengdu 611731,China;Sichuan Province Key Lab of Personalized Drug Therapy,the Affiliated Hospital of University of Electronic Science and Technology of China/Sichuan Provincial People's Hospital,Chengdu 610072,China)
出处
《医药导报》
CAS
北大核心
2023年第2期203-207,共5页
Herald of Medicine
基金
国家重点研发计划(2020YFC2005500)
四川省干部保健科研课题(川干研2021-226)
个体化药物治疗四川省重点实验室开放课题(2021ZD01)
四川省科技厅重点研发计划(2019YFS0514)
四川省人民医院院级科研基金临床研究及转化项目(2017Y16)。
关键词
丁苯酞
帕金森病
抗脑缺血
Butylphthalide
Parkinson's disease
Anti-cerebral ischemia
