摘要
目的分析结直肠癌患者新辅助化疗期间CT三维血管重建技术对治疗效果的评估价值。方法选定本院2018年8月至2021年8月住院的90例结直肠癌患者,均给予5-氟尿嘧啶+亚叶酸钙+奥沙利铂(FOLFOX6)新辅助化疗治疗,治疗前后均进行CT三维血管重建技术检查,比较治疗前后血清基质金属蛋白酶-9(MMP-9)、血管内皮生长因子(VEGF)、肿瘤血管密度、最大病灶直径,统计治疗效果、淋巴结转移率,比较有、无淋巴结转移组肿瘤血管密度、最大病灶直径,绘制受试者工作特征曲线(ROC)分析肿瘤血管密度、最大病灶直径对结直肠癌患者淋巴结转移预测价值。结果治疗后血清MMP-9、VEGF均比治疗前低(P<0.05)。治疗后肿瘤血管密度、最大病灶直径均低于治疗前(P<0.05)。90例患者经FOLFOX6新辅助化疗治疗,总有效率是86.7%(78/90),淋巴结转移率是3.3%(3/90)。肿瘤血管密度、最大病灶直径对结直肠癌患者淋巴结转移预测灵敏度分别是87.2%、81.4%,特异度分别是93.25%、85.37%。结论CT三维血管重建技术可对结直肠癌患者FOLFOX6新辅助化疗治疗效果做出准确评价,通过测量肿瘤血管密度、最大病灶直径,还可以预测淋巴结转移,具有一定临床价值。
Objective To analyze the evaluation value of CT three-dimensional vascular reconstruction technology for the treatment effect of colorectal cancer patients during neoadjuvant chemotherapy. Methods Ninety patients with colorectal cancer who were hospitalized in our hospital from August 2018 to August 2021 were selected and given FOLFOX6(5-fluorouracil + leucovorin + oxaliplatin) neoadjuvant chemotherapy. CT three-dimensional vascular reconstruction technology examination, comparison of serum matrix metalloproteinase-9(MMP-9), vascular endothelial growth factor(VEGF), tumor vascular density, maximum lesion diameter before and after treatment,statistical treatment effect, lymph node metastasis rate, compared with and without The tumor blood vessel density and the largest lesion diameter in the lymph node metastasis group were plotted, and the ROC curve was drawn to analyze the predictive value of the tumor blood vessel density and the largest lesion diameter for lymph node metastasis in colorectal cancer patients. Results After treatment, serum MMP-9 and VEGF were lower than those before treatment,(P<0.05). After treatment, tumor vessel density and maximum lesion diameter were lower than those before treatment,(P<0.05). 90 patients were treated with FOLFOX6 neoadjuvant chemotherapy, the total effective rate was 86.7%(78/90), and the lymph node metastasis rate was 3.3%(3/90). The sensitivities of tumor vessel density and the largest lesion diameter for predicting lymph node metastasis in colorectal cancer patients were 87.2% and 81.4%,respectively, and the specificities were 93.2% and 85.4%, respectively. Conclusion CT three-dimensional vascular reconstruction technology can accurately evaluate the effect of FOLFOX6 neoadjuvant chemotherapy in patients with colorectal cancer. By measuring tumor vascular density and maximum lesion diameter, it can also predict lymph node metastasis, which has certain clinical value.
作者
刘跃权
梅韬
Liu Yuequan;Mei Tao(Department of Radiology,Zhaotong First People′s Hospital,Yunnan 657000,China)
出处
《实用医学影像杂志》
2022年第6期596-599,共4页
Journal of Practical Medical Imaging
关键词
结直肠肿瘤
放化疗
辅助
体层摄影术
X线计算机
治疗效果
三维血管重建技术
Colorectal neoplasms
Chemoradiotherapy
adjuvant
Tomography
X-ray computed
Treatment outcome
Three-dimensional vascular reconstruction technology
