摘要
目的:系统评价单用中药制剂治疗儿童反复呼吸道感染的临床疗效和安全性,为临床诊疗中合理应用中药提供循证依据。方法:使用计算机检索PubMed、EMbase、中国生物医学文献数据库、中国知网、维普数据库和万方数据库知识服务平台,收集单用中药制剂(治疗组)对比西药常规治疗(对照组)治疗儿童反复呼吸道感染的随机对照试验,检索时间为2016—2021年,运用NoteExpress软件并严格遵循纳入标准、排除标准对所得文献进行重复文献剔除、筛选、质量评价,再采用RevMan 5.3软件对最终数据进行Meta分析。结果:最终纳入30篇文献,共5 998例患儿,其中治疗组患儿3 005例,对照组患儿2 993例。Meta分析结果显示在治疗总有效率、患儿免疫指标[免疫球蛋白(Immunoglobulin,Ig)A、Ig G、Ig M]、治疗后发病次数等主要观察指标上,治疗组数据均优于对照组,且差异具有统计学意义(P<0.05)。结论:运用中药治疗儿童反复呼吸道感染有显著疗效,能够明显提高患儿的免疫力、减少呼吸道感染发病次数,具有独特的优势和作用,值得临床推广应用。在本次研究中,考虑到所纳入的部分文献的质量不高以及可能存在的发表偏倚,在今后的研究中尚需开展更高质量的研究加以验证。
Objective:To systematically evaluate the clinical efficacy and safety of TCM medicine alone in the treatment of recurrent respiratory tract infection in children,so as to provide evidence-based basis for rational use of TCM medicine in clinical diagnosis and treatment.Methods:Pub Med,EMbase,China Biomedical Literature Database,China knowledge Network,VIP Database and Wanfang Database knowledge service platform were searched by computer to collect the randomized controlled trial of TCM medicine alone(the treatment group),which was compared with Western medicine routine treatment(the control group) in the treatment of recurrent respiratory tract infection in children from 2016 to 2021.Note Express software was used,and the inclusion criteria and exclusion criteria for repetitive literature elimination were strictly followed for screening,quality evaluation.Rev Man 5.3 software was used for a meta-analysis of the final data.Results:A total of 5 998 cases were included in 30 studies,including 3 005 cases in the treatment group and 2 993 cases in the control group.The results of the meta-analysis showed that the treatment group was better than the control group in the main observation indexes such as the total effective rate of treatment,the immune indexes of children(Ig A,Ig G,Ig M) and the frequency of onset after treatment(P<0.05).Conclusion:The use of TCM medicine in the treatment of recurrent respiratory tract infection in children has a significant effect,it can significantly improve the immunity of children,reduce the incidence of respiratory tract infection,has unique advantages and effects,and is worthy of clinical application.In this study,the low quality of some of the included literature and the possible publication bias is taken into account,therefore,higher quality research needs to be carried out to verify the conclusion in the future.
作者
邵颖月
陈慧
李丽丽
SHAO Yingyue;CHEN Hui;LI Lili
出处
《中医临床研究》
2022年第30期96-100,共5页
Clinical Journal Of Chinese Medicine
基金
天津中医药大学第二附属医院青苗计划(QMJH202027)。
关键词
儿童
反复呼吸道感染
中药
Children
Recurrent respiratory tract infection
TCM medicine
