摘要
目的:评估姜石颗粒治疗急性胃肠炎的综合疗效、主要临床症状疗效及症状消失时间。方法:选取2015年6月―2020年6月甘肃中医药大学附属医院脾胃病科急性胃肠炎患者84例,采用随机数字表法将患者分为姜石颗粒组、微生态制剂组和对照组各28例。在治疗过程中,姜石颗粒组例因治疗后症状好转后期未能接受姜石颗粒治疗,剔除微生物制剂组患者脱失7例;对照组无脱落、失访、剔除最终完成试验者58例,其中对照组28例,微生态制剂组21例,姜石颗粒组9例。三组均予以清淡饮食、纠正水电解质紊乱、抗感染等基础治疗。对照组仅给予基础治疗;微生态制剂组在基础治疗上给予微生态制剂双歧杆菌三联活菌片(或双歧杆菌四联活菌片)治疗;姜石颗粒组在微生态制剂组治疗的基础上加用姜石颗粒治疗,三组均治疗7 d。评价治疗中患者每天的主要临床症状(腹痛、腹泻、呕吐)及症状消失时间,并对其安全性进行评价。结果:姜石颗粒组临床疗效总有效率为88.89%(8/9),微生态制剂组66.67%(14/21),对照组64.28%(18/28),三组患者治疗后的综合疗效比较差异无统计学意义(P>0.05)。治疗后,姜石颗粒组患者治疗后腹痛、腹泻症状积分均较治疗前低,差异有统计学意义(P<0.05);姜石颗粒组腹泻、腹痛、恶心呕吐症状疗效积分均较其他两组低,差异有统计学意义(P<0.05);姜石颗粒组治疗后各主要临床症状消失时间均小于其他两组,差异均有统计学意义(P<0.05),没有发现与姜石颗粒内服相关的不良反应。结论:姜石颗粒组、微生态制剂组和对照组治疗后综合疗效相同,但姜石颗粒联合微生态制剂治疗可以改善急性胃肠炎腹痛、腹泻症状;且在控制腹痛、腹泻、恶心呕吐3种临床症状及缩短上述症状时间上,姜石颗粒组明显优于其他两组,且临床使用安全。
Objective:To investigate the comprehensive efficacy,the efficacy of main clinical symptoms and the efficacy of disappearance time of symptoms of the Jiangshi granules(姜石颗粒)on acute gastroenteritis.Methods:The 84 patients with acute gastroenteritis admitted in the Department of spleen and stomach Diseases,affiliated Hospital of Gansu University of traditional Chinese Medicine from June 2015 to June 2020 were randomly divided into the Jiangshi granules group(28 cases),microecological preparation group(28 cases)and control group(28 cases).In the course of treatment,the 19 patients in the Jiangshi granules group could not receive the Jiangshi granules treatment in the later stage;7 patients in the microbial preparation group lost;and 28 patients in the control group had no shedding,loss of follow-up and elimination.The 58 cases finally completed the test,including the control group(28 cases),the microecological preparation group(21 cases)and the Jiangshi granules group(9 cases).All the three groups were given basic treatment such as light diet,correction of water and electrolyte disturbance,anti-infection and so on.The control group was only given basic treatment.The microecological preparation group was treated with bifidobacterium triple live bacteria tablet(or bifidobacterium quadruple live bacteria tablet)based on the basic treatment.The Jiangshi granules group was treated with the Jiangshi granules on the basis of the treatment in the microecological preparation group.All the three groups were treated for 7 days.The main clinical symptoms(abdominal pain,diarrhea,vomiting)and the disappearance time of symptoms were evaluated,and their safety was evaluated.Results:The total effective rate in the Jiangshi granule group,microecological preparation group and control group were 88.89%(8/9),66.67%(14/21)and 64.28%(18/28)(P>0.05),respectively after treatment,the scores of abdominal pain and diarrhea in the Jiangshi granules group were lower than those in the other two groups before treatment(P<0.05).The curative effect scores of diarrhea,abdominal pain,nausea and vomiting in the Jiangshi granules group were significantly lower than those in the other two groups(P<0.05),and the disappearance time of main clinical symptoms in the Jiangshi granules group was significantly shorter than that in the other two groups(P<0.05),and no adverse reactions related to oral administration of the Jiangshi granules were found.Conclusion:Three groups have the same comprehensive effect after treatment,but the Jiangshi granules plus microecological preparation can relieve the symptoms of abdominal pain and diarrhea in acute gastroenteritis patients.The Jiangshi granules group is obviously superior to the other two groups in controlling abdominal pain,diarrhea,nausea and vomiting,and shortening the appearance time of above symptoms,and it is safe in clinical use.
作者
邹雅
罗十之
ZHOU Ya;LUO Shizhi
出处
《中医临床研究》
2022年第30期118-121,共4页
Clinical Journal Of Chinese Medicine
关键词
急性胃肠炎
姜石颗粒
微生态制剂
疗效
Acute gastroenteritis
The Jiangshi granules
Microecological preparation
Curative effect
