摘要
目的:观察温肾健脾利水方联合缬沙坦胶囊治疗脾肾气虚型慢性肾小球肾炎(CG)临床疗效。方法:选取443例CG患者作为研究对象,按随机数字表法分为观察组222例和对照组221例。对照组予以缬沙坦胶囊治疗,观察组予以缬沙坦胶囊联合温肾健脾利水方治疗,2组均持续治疗2个月。观察2组临床疗效及不良反应发生率,比较2组治疗前后中医证候积分、肾功能指标[尿素氮(BUN)、血肌酐(SCr)、尿蛋白定量(Upr)]及炎症因子[白细胞介素-6 (IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α (TNF-α)]水平的变化。结果:观察组临床疗效总有效率为95.05%,对照组为90.05%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组头晕目眩、尿液浑浊及尿血的中医证候积分均较治疗前下降(P<0.05),观察组上述3项中医证候积分均低于对照组(P<0.05)。治疗后,2组BUN、SCr、Upr水平均较治疗前下降(P<0.05),观察组上述3项水平均低于对照组(P<0.05)。治疗后,2组CRP、IL-6、TNF-α水平均较治疗前下降(P<0.05),观察组上述3项水平均低于对照组(P<0.05)。治疗后,观察组不良反应发生率为4.95%,对照组为7.24%,2组比较,差异无统计学意义(P>0.05)。结论:温肾健脾利水方联合缬沙坦胶囊治疗CG可提高临床疗效,缓解临床症状,降低炎症反应,提高肾功能。
Objective:To observe the clinical effect of Wenshen Jianpi Lishui Prescription combined with Valsartan Capsules in treating chronic glomerulonephritis(CG) of spleen-kidney qi deficiency type.Methods:A total of 443 cases of CG patients were selected as the study objectives and divided into the observation group and the control group according to the random number table method,with 222 and221 cases in each group respectively.The control group was treated with Valsartan Capsules,and the observation group was treated with Wenshen Jianpi Lishui Prescription combined with Valsartan Capsules.Both groups were treated for two months.Clinical effects and the incidences of adverse reactions in the two groups were observed.Changes in Chinese medicine syndrome scores,the kidney function indexes[blood urea nitrogen(BUN),serum creatinine(SCr),urine protein ratio(Upr)],and inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)] before and after treatment in the two groups were compared.Results:The total clinical effective rate was 95.05% in the observation group and 90.05% in the control group,the difference being significant(P0.05).Conclusion:In the treatment of CG,Wenshen Jianpi Lishui Prescription combined with Valsartan Capsules can enhance clinical effect,relieve clinical symptoms,reduce inflammatory responses,and improve the kidney function.
作者
杨琳
高淑婷
许欢
YANG Lin;GAO Shuting;XU Huan
出处
《新中医》
CAS
2022年第23期93-97,共5页
New Chinese Medicine
关键词
慢性肾小球肾炎
脾肾气虚型
温肾健脾利水方
缬沙坦胶囊
肾功能
Chronic glomerulonephritis
Spleen-kidney qi deficiency type
Wenshen Jianpi Lishui Prescription
Valsartan Capsules
Kidney function
