摘要
目的:观察龙钻通痹颗粒内服联合五方散外敷对类风湿关节炎活动期患者的临床疗效。方法:按照随机数字表法将60例活动期的类风湿关节炎患者随机分为对照组和观察组各30例。对照组予基础治疗,包括临床宣教及西药口服;观察组在对照组基础上加服龙钻通痹颗粒,并以五方散外敷疼痛部位。比较两组中医症状评分、汉密尔顿抑郁量表(HAMD)和焦虑量表(HAMA)评分、生活质量指数量表(SQLI)评分,以及红细胞沉降率(ESR)、血清C反应蛋白(CRP)、类风湿因子(RF)水平,观察不良反应情况,评估临床疗效。结果:治疗后,观察组和对照组总有效率分别为93.3%和66.7%,观察组疗效优于对照组(P<0.05);治疗后,两组中医症状评分、HAMD评分、HAMA评分,及CRP、ESR、RF水平均低于治疗前,SQLI评分均高于治疗前,且观察组改善更明显,差异均有统计学意义(P<0.05);两组均未出现严重不良反应情况。结论:龙钻通痹颗粒口服联合五方散外敷治疗类风湿关节炎活动期可有效改善患者临床指征,且安全性高。
Objective:To observe the clinical effect of Longzuan Tongbi Granule(龙钻通痹颗粒)combined with Wufang Powder(五方散)applied externally on patients with active stage of rheumatoid arthritis.Methods:According to the random number table method,60 patients with active stage of rheumatoid arthritis were divided into 2 groups,30 cases in control group and 30 cases in observation group.Patients in control group were given basic treatment,including clinical education and oral western medicine.Patients in the observation group were treated with oral Longzuan Tongbi Granule and Wufang Powder externally applied to the painful parts at the same time.Traditional Chinese medicine(TCM)symptom score,Hamilton Depression Scale(HAMD)and Anxiety Scale(HAMA)and spitzer quality of life index(SQLI)scores,the levels of erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and rheumatoid factor(RF)were compared between the two groups.The reverse effect and efficacy of two gropus were evaluated.Results:After treatment,the total effective rate in the observation group was 93.3%and that in the control group was 66.7%,the difference was statistically significant(P<0.05).The scores of TCM symptom,HAMD and HAMA,and the levels of CRP,ESR and RF of the two groups were higher than those before treatment,and SQLI score of the two groups were higher than that before treatment,and the observation group was better than the control group.The differences were statistically significant(P<0.05).There was no significant reverse effect during the treatment in both groups.Conclusion:Longzuan Tongbi Granule and Wufang Powder external application in the treatment of patients with rheumatoid arthritis in active stage can effectively improve the clinical indications safely.
作者
杨雅麟
陈延强
黄筱瑛
覃坤兰
YANG Yalin;CHEN Yanqiang;HUANG Xiaoying;QIN Kunlan(Department of Rheumatology,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)
出处
《山东中医杂志》
2023年第2期127-131,共5页
Shandong Journal of Traditional Chinese Medicine
基金
国家重点研发计划项目(编号:2017YFC1704004)
广西高校壮医方药基础与应用研究重点实验室系统性课题(批文号:桂教科研〔2016〕6号zyfy201606)。
关键词
类风湿关节炎
活动期
龙钻通痹颗粒
五方散
寒湿痹阻
rheumatoid arthritis
active stage
Longzuan Tongbi Granule
Wufang Powder
cold and dampness obstruction
