摘要
Surgical quality is critical in cancer treatment,as it not only determines the radical resection of the primary tumor but also allows expedited postoperative recovery and early continuation of adjuvant therapy.Postoperative complications are valuable met-rics for assessing surgical quality.In gastric and colorectal cancer surgeries,postoperative complications substantially postpone patients'recovery and,in extreme cases,pose life-threatening risks[1].
PACAGE研究旨在报告中国胃癌和结直肠癌术后腹部并发症的流行病学概况.来自全国20个中心参与该研究并通过网络登记系统于2018年11月~2020年12月期间前瞻性登记入组手术患者的手术及康复情况,同时根据中国专家共识及Clavien-Dindo系统(CDC)对并发症及其严重程度进行登记分级.研究最终分析纳入3926例患者(胃癌组2271例,结直肠癌组1655例).共有16.73%的患者发生并发症(胃癌组18.14%,结直肠癌组14.80%).胃癌手术最常见的术后并发症是腹腔感染(7.22%,包括吻合口漏)及呼吸道感染(3.92%).结直肠癌手术最常见的术后并发症是腹腔感染(7.25%,包括吻合口漏)及切口感染(3.50%).在所有入组患者中,严重并发症发生率为3.13%(CDC-Ⅲ2.73%,CDC-Ⅳ0.23%),包括7例术后死亡(0.18%).术后并发症患者住院时间、费用和炎症指标均显著上升(P<0.05).该研究首次报告了我国多个代表性中心的胃结直肠癌术后腹部并发症的横断面流行病学概况,可作为基准为后续研究和政策制定提供参考.
作者
Zhouqiao Wu
Su Yan
Zining Liu
Changqing Jing
Fenglin Liu
Jiang Yu
Zhengrong Li
JianZhang
Lu Zang
Hankun Hao
Chaohui Zheng
Yong Li
Lin Fan
Hua Huang
Pin Liang
Bin Wu
Jiaming Zhu
Zhaojian Niu
Linghua Zhu
Wu Song
Jun You
Qi Wanga
Ziyu Li
Jiafu Ji
on behalf of the PACAGE study group
吴舟桥;燕速;刘子宁;靖昌庆;刘凤林;余江;李正荣;张健;臧璐;蒿汉坤;郑朝辉;李勇;樊林;黄华;梁品;吴斌;朱甲明;牛兆建;朱玲华;宋武;尤俊;王琦;李子禹;季加孚;PACAGE研究学组(Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Gastrointestinal Cancer Center,Peking University Cancer Hospital&Institute,Beijing 100142,China;Department of Gastrointestinal and Oncological Surgery,Affiliated Hospital(&Clinical College)of Qinghai University,Xining 810001,China;Department of Gastrointestinal Surgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China;Department of General Surgery,Fudan University Zhongshan Hospital,Shanghai 200032,China;Department of General Surgery,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Department of General Surgery,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China;Department of General Surgery,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;Department of General Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of General Surgery,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Gastric Surgery,Fujian Medical University Union Hospital,Fuzhou 350001,China;Department of General Surgery,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China;Department of General Surgery,The First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710061,China;Department of Gastric Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China;Department of Gastrointestinal Surgery,The First Affiliated Hospital,Dalian Medical University,Dalian 116011,China;Department of General Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Gastrointestinal Surgery,The Second Affiliated Hospital of Jilin University,Changchun 130041,China;Department of General Surgery,The Affiliated Hospital of Qingdao University,Qingdao 266003,China;Department of General Surgery,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China;Department of Gastrointestinal Surgery,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510275,China;Gastrointestinal Surgery Department II,Xiamen Oncology Hospital,First Affiliated Hospital,Xiamen University,Xiamen 361003,China;不详)
基金
supported by the National Natural Science Foundation of China(U20A20371)
the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(D171100006517004)
Beijing Municipal Administration of Hospitals’Youth Program(QML20191103)
Clinical Medicine Plus X-Young Scholars Project,Peking University
the Fundamental Research Funds for the Central Universities
the Science Foundation of Peking University Cancer Hospital。
