摘要
目的探究双歧杆菌四联活菌联合常规用药治疗痛风的效果,为该类患者的治疗提供参考。方法选取2018年12月至2020年12月我院300例痛风患者作为研究对象进行前瞻性研究,按照随机数字表法按1∶1比例分为联合组和常规组,各150例。常规组患者采用常规治疗,联合组在常规组基础上加用双歧杆菌四联活菌。比较2组患者疗效,治疗前后血尿酸、粪便中尿酸、粪便中细菌分解的尿酸、肠道菌群(双歧杆菌、乳杆菌、拟杆菌、大肠埃希菌)、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、环氧化酶-2(COX-2)、白细胞介素-6(IL-6)]水平、血管内皮功能[可溶性细胞间黏附分子-1(sICAM-1)、一氧化氮(NO)、内皮素-1(ET-1)]及不良反应发生率。结果联合组患者总有效率(91.33%)高于常规组(83.33%),差异有统计学意义(P<0.05)。治疗后联合组患者血尿酸、粪便中尿酸水平低于常规组,粪便中细菌分解的尿酸水平高于常规组(均P<0.05)。治疗后联合组患者肠道双歧杆菌、乳杆菌数量高于常规组,拟杆菌、大肠埃希菌数量低于常规组(均P<0.05)。治疗后联合组患者血清IL-1β、TNF-α、COX-2、IL-6、sICAM-1、ET-1水平低于常规组,而NO水平高于常规组(均P<0.05)。2组患者不良反应发生率差异无统计学意义(P>0.05)。结论双歧杆菌四联活菌辅助治疗痛风的效果显著,可有效降低尿酸水平,调节肠道菌群稳定,缓解机体炎症,改善血管内皮功能,安全性较高。
Objective To explore the effect of quadruple viable Bifidobacterium combined with conventional medication in the treatment of gout,providing a reference for the treatment.Methods A total of 300 gout patients in our hospital from January 2018 to December 2020 were selected as the subjects of the prospective research.The patients were randomly divided into a combination group or a control group at a ratio of 1∶1,with 150 cases in each group.Both groups were treated with conventional treatment,and the combination group was additionally treated with quadruple viable Bifidobacterium.The efficacy,blood uric acid,uric acid in stool,bacteria-decomposed uric acid in stool,intestinal flora(Bifidobacterium,Lactobacillus,Bacteroides,Escherichia coli),inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),cyclooxygenase-2(COX-2),interleukin-6(IL-6)],vascular endothelial function[soluble intercellular adhesion Molecule-1(sICAM-1),nitric oxide(NO),endothelin-1(ET-1)]before and after treatment,and the incidence of adverse reactions were compared between the two groups.Results The total efficiency rate was 91.33%in the combination group,higher than the 83.33%in the control group(P<0.05).After treatment,the blood uric acid and uric acid in feces in combination group were lower,and the bacteria-decomposed uric acid in feces was higher than those in the control group,respectively(all P<0.05).After treatment,the Bifidobacterium and Lactobacillus in the combination group were higher,while Bacteroides and Escherichia coli were lower than those in the control group,respectively(all P<0.05).After treatment,the serum levels of IL-1β,TNF-α,COX-2,IL-6,sICAM-1 and ET-1 in the combination group were lower,while that of NO was higher than in the control group,respectively(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The quadruple viable Bifidobacterium is effective in adjuvant treatment of gout,which can effectively reduce the level of uric acid,regulate the stability of intestinal flora,relieve body inflammation,and improve vascular endothelial function,with high safety.
作者
黄晓琳
王志文
HUANG Xiao-lin;WANG Zhi-wen(Department of General Medicine,Huizhou Central People's Hospital,Huizhou,Guangdong 516001,China)
出处
《中国微生态学杂志》
CAS
CSCD
2022年第11期1324-1329,共6页
Chinese Journal of Microecology
基金
惠州市科技计划(医疗卫生项目,2018Y016)。
关键词
双歧杆菌四联活菌
痛风
肠道微生态
尿酸
血管内皮功能
Bifidobacterium quadruple viable
Gout
Intestinal microecology
Uric acid
Vascular endothelial function
