摘要
目的为医疗机构规范头孢菌素类药物皮试的执行标准提供参考。方法调取2018年4月—2019年3月(实施前)、2019年4月—2020年3月(实施后)各病区使用过头孢菌素的病例,对两组皮试率及过敏反应发生情况进行回顾性分析。结果实施皮试管理规定后,全院头孢菌素皮试率由97.81%下降至70.71%,前后比较差异有统计学意义(P<0.01),其中临床药师重点参与宣教干预的妇、产、儿科病区皮试率分别从99.91%降至6.58%、98.9%降至8.13%、100%降至17.37%。说明书明确规定需皮试的品种用量较前下降33.28%。两组过敏反应发生率并无明显差异(P>0.05)。结论为保证医疗质量和医疗安全,头孢菌素类药物皮试亟待规范。建议取消头孢普遍筛查,做好详细询问过敏史和防范救治措施更为重要。
Objective To provide references for medical institutions to standardize the implementation of standard cephalosporin drug skin test.Methods From April 2018 to March 2019(before the implementation)and from April 2019 to March 2020(after the implementation),the data of patients who had received cephalosporin in each ward were collected.The skin test and the occurrence of allergic reactions in the two groups were analyzed retrospectively.Results After the implementation of the skin test management regulations,the skin test rate of cephalosporin in the whole hospital decreased from 97.81%to 70.71%,and the difference was statistically significant(P<0.01).The skin test rate in the gynecology,obstetrices,and pediatrics wards mainly involved in the direct education intervention decreased from 99.91%to 6.58%,98.9%to 8.13%,and 100%to 17.37%,respectively.The specification clearly stipulated that the amount of varieties to be skin tested was 33.28%lower than before.There was no significant difference in the incidence of allergic reactions between the two groups(P>0.05).Conclusion In order to ensure medical quality and safety,skin test of cephalosporins should be standardized urgently.It is recommended to cancel the universal cephalosporin screening,and it is more important to inquire about the history of allergy and provide preventive treatment measures.
作者
闫琴琴
吴雪
Yan Qin-qin;Wu Xue(Department of Pharmacy,the 924^(th)Hospital of PLA Joint Service Support Force,Guilin 541002)
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2022年第11期1216-1219,共4页
Chinese Journal of Antibiotics
关键词
头孢菌素
皮试
过敏反应
Cephalosporin
Skin test
Allergic reaction
