摘要
目的 观察慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)患者血清白细胞介素-1β(IL-1β)、白细胞介素-35(IL-35)表达情况,并分析二者与术后复发的相关性。方法 选取2017年1月—2021年6月于丽水市人民医院接受手术治疗的66例CRSwNP患者为研究对象,所有患者入院时均接受血清IL-1β、IL-35水平检测,并对所有术后患者进行为期1年的随访,统计其复发情况,分析慢性鼻-鼻窦炎伴息肉患者血清IL-1β、IL-35水平与术后复发的相关性。结果 随访1年,66例CRSwNP患者术后复发23例,占34.85%;复发组血清IL-5、IL-1β、IL-35水平均高于未复发组,差异有统计学意义(P<0.05);经点二列相关性分析,结果显示,血清IL-5、IL-1β、IL-35水平与CRSwNP患者术后复发相关(P<0.05);绘制受试者工作特征(ROC)曲线,结果显示,血清IL-1β、IL-35水平评估CRSwNP患者术后复发的曲线下面积(AUC)均>0.7,具有一定评估价值,其中联合评估价值最高。结论 CRSwNP患者血清IL-1β、IL-35水平升高,且二者与术后复发密切相关。
Objective This study aims to observe the expression of serum interleukin-1β(IL-1β) and interleukin-35(IL-35) in patients with chronic rhinosinusitis with nasal polyps(CRSwNP) and analyze the correlation between them and postoperative recurrence of CRSwNP. Methods A total of 66 patients with CRSwNP who underwent surgery in Lishui People’s Hospital from January 2017 to June 2021 were selected as the research subjects. All patients’ serum IL-1β and IL-35 levels were detected at admission, and all patients were followed up for one year. The correlation between the levels of serum IL-1β and IL-35 and postoperative recurrence of CRSwNP was analyzed. Results After one-year’s follow-up, CRSwNP recurred in 23 of the 66 patients, accounting for 34.85%;the serum levels of IL-5, IL-1β and IL-35 in the recurrence group were significantly higher than those in the non-recurrence group, and the differences were statistically significant(P<0.05);the point-biserial correlation analysis showed that the serum levels of IL-5, IL-1β and IL-35 were correlated with postoperative recurrence of CRSwNP(P<0.05);the receiver operating characteristic(ROC) curve showed that the area under the curve(AUC) of postoperative recurrence in patients with CRSwNP was less than 0.7 in reference with the serum levels of IL-1β and IL-35, which had certain appraisal value, but the joint appraisal value was the highest. Conclusion The serum levels of IL-1β and IL-35 in patients with CRSwNP are significantly increased, and they are closely related to postoperative recurrence.
作者
徐开睿
王小飞
黄武
章誉耀
XU Kai-rui;WANG Xiao-fei;HUANG Wu;ZHANG Yu-yao(Department of Otolaryngology,Head and Neck Surgery,Lishui People's Hospital,Zhejiang 323000,China)
出处
《中国卫生检验杂志》
CAS
2022年第23期2900-2903,共4页
Chinese Journal of Health Laboratory Technology
