摘要
中性粒细胞在固有免疫中具有重要作用,它活化后释放的中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)在抗感染中发挥积极作用,然而过量的NETs会导致机体功能障碍和器官损害,参与疾病的病理生理过程。现就子痫前期、妊娠期糖尿病、早产等产科相关疾病中NETs的形成原因、调节机制、参与疾病的病理生理过程展开综述,同时对现有阻断NETs形成的产科常用药物进行总结。
Neutrophils plays an essential role in innate immunity.Neutrophil extracellular traps(NETs)are released by activated neutrophils in response to infection.However,excessive NETs can result in body dysfunction and organ damage and participate in several pathological conditions.This paper mainly focuses on the formation,regulatory mechanism and role of NETs in obstetric diseases,such as preeclampsia,gestational diabetes mellitus and preterm birth,and listed the current medications used to block the formation of NETs in obstetrics.
作者
申迪
王谢桐
Shen Di;Wang Xietong(Department of Obstetrics and Gynecology,Maternal and Child Health Care Hospital of Shandong Province,Jinan 250014,China;Cheeloo College of Medicine,Shandong University,Jinan 250102,China;Department of Obstetrics and Gynecology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China;Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China,Jinan 250014,China)
出处
《中华围产医学杂志》
CAS
CSCD
北大核心
2022年第12期991-995,共5页
Chinese Journal of Perinatal Medicine
基金
国家自然科学基金(81873842)
山东省中医药科技项目(2021Q129)
山东省医药卫生科技发展计划(202105020991)。
关键词
妊娠
胞外诱捕网
子痫前期
糖尿病
妊娠
早产
Pregnancy
Extracellular traps
Pre-eclampsia
Diabetes,gestational
Premature birth
