摘要
非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)感染引起的猪的一种高度接触性、致死性传染病,病死率可达100%,世界动物卫生组织(OIE)将其列为必须报告的疫病,在我国被列为一类动物疫病。因ASFV具有庞大的基因组和复杂的免疫逃逸机制,给疫苗的研发带来了困难,目前尚无商品化的疫苗用于本病的防制。为了更深入地了解ASFV,加快ASF疫苗的研发进程,做到对ASF的有效防制,重点对ASFV基础病毒学的最新研究发现与成果进行综述,主要集中在ASFV的蛋白质功能与作用机制、诊断方法以及疫苗的开发进展方面,以期为ASF的有效防制奠定基础。
African swine fever(ASF)is an acute infectious disease of pigs caused by African swine fever virus(ASFV)infection,which is classified as a notifiable disease by the World Organization for Animal Health(OIE)and classified as a class one animal disease in China.ASFV has a large genome and a complex immune escape mechanism,which makes it difficult to develop a vaccine.Currently,there is no commercial vaccine for the prevention and control of ASFV.In order to better understand ASFV and accelerate the development of ASF vaccine to effectively prevent and control ASF,this paper focuses on the latest research findings and achievements in basic virology of ASFV,focusing on the protein function and mechanism of action,diagnostic methods and vaccine development of ASFV to lay foundation for the prevention and control of ASF.
作者
张帅
刘媛
赵云环
刘莹
左玉柱
范京惠
ZHANG Shuai;LIU Yuan;ZHAO Yunhuan;LIU Ying;ZUO Yuzhu;FAN Jinghui(College of Veterinary Medicine,Hebei Agricultural University,Baoding,Hebei 071001,China;Xingdong New District Social Development Institute of Animal Health Supervision,Xingtai,Hebei 054000,China;Hebei Veterinary Biotechnology Innovation Center,Baoding,Hebei 071001,China)
出处
《中国兽医学报》
CAS
CSCD
北大核心
2022年第12期2569-2577,共9页
Chinese Journal of Veterinary Science
基金
河北省省级科技计划资助项目(21326611D,19226622D)
河北省农业产业技术体系生猪创新团队资助项目(HBCT2018110207)。
关键词
非洲猪瘟病毒
蛋白功能
诊断方法
非洲猪瘟疫苗
African swine fever virus
protein function
diagnostic methods
ASF vaccine
