摘要
儿童急性肝衰竭(PALF)是多种病因引起的罕见、危及生命的临床综合征,病情凶险,进展迅猛,病死率高。如何早期识别肝衰竭及准确评估肝移植介入时机,是降低肝衰竭病死率的关键。传统的血液生物学标志物可用于PALF的诊断、病情评估以及辅助制定治疗策略,近年来新型的生物学标志物在PALF的诊断和病情评估方面开拓了新思路。本文根据肝脏生物学功能,梳理传统生物学标志物及新型生物学标志物的临床意义,以期提高对PALF的诊治能力。
Pediatric acute liver failure(PALF)is a rare and life-threatening clinical syndrome caused by multiple etiologies with high mortality,rapid progress and bad prognosis.It′s crucial that how to identify liver failure early and evaluate the operation opportunity of liver transplantation accurately.Traditional serum biomarkers can be used to diagnose and evaluate the conditions of PALF,and they can also provide suggestions for treatment.In recent years,some new biomarkers of PALF have been emerged.This review summarized the traditional biomarkers and new biomarkers according to liver′s biological functions,aiming to improve the ability of clinicians to diagnose and treat PALF.
作者
张圳
张晓燕
李玉梅
Zhang Zhen;Zhang Xiaoyan;Li Yumei(Department of PICU,the First Hospital of Jilin University,Changchun 130021,China)
出处
《中国小儿急救医学》
CAS
2022年第12期946-950,共5页
Chinese Pediatric Emergency Medicine
