摘要
目的 探讨重症监护病房(intensive care unit,ICU)脓毒症患者应用低分子肝素抗凝治疗对患者免疫功能、凝血功能及炎症指标的影响。方法 选取2020年1月至2022年7月台州市第一人民医院收治的ICU脓毒症患者80例为研究对象,采用随机数字表法分为对照组(n=40)和观察组(n=40)。对照组采用常规治疗,观察组在常规治疗基础上给予低分子肝素抗凝治疗,比较两组患者的免疫功能、凝血功能和炎症指标水平。结果 治疗后,观察组各项免疫指标(CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+))水平的改善情况均优于对照组,差异有统计学意义(P<0.05)。治疗后,凝血酶原时间、活化部分凝血活酶时间水平组间比较,观察组低于对照组,纤维蛋白原水平组间比较,观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组白细胞介素-6、C反应蛋白、白细胞介素-10、肿瘤坏死因子-α水平均低于对照组,差异有统计学意义(P<0.05)。结论 ICU脓毒症使用低分子肝素抗凝治疗,在提高机体免疫功能,降低炎症反应和改善凝血功能等方面,均能发挥较好的效果,临床应用价值高。
Objective To explore the effect of low molecular weight heparin anticoagulation on the immune function, coagulation function and inflammatory index of septic patients in intensive care unit(ICU). Methods A total of 80 patients admitted to ICU of Taizhou First People’s Hospital from January 2020 to July 2022 were selected and divided into the control group(n=40) and the observation group(n=40) according to random number table. The control group was treated with routine therapy, and the observation group was treated with low molecular weight heparin on the basis of routine therapy. The immune function, coagulation function,inflammatory index of the two groups were compared. Results After treatment, the improvement of immune indexes(CD3^(+), CD4^(+)and CD4^(+)/CD8^(+)) in the observation group were better than those in the control group, the differences were statistically significant(P<0.05). The level of prothrombin time and activated partial thromboplastin time after treatment in the observation group were lower than those in the control group, and the level of fibrinogen in the observation group was higher than that in the control group, the differences were statistically significant(P<0.05). After treatment, compared with the control group, the C reactive protein, tumor necrosis factor-α, interleukin-6 and interleukin-10 in the observation group were lower, the differences were statistically significant(P<0.05). Conclusion The anticoagulant therapy with low molecular weight heparin in ICU sepsis can play a good role in improving immune function, reducing inflammatory reaction and improving coagulation function, and has high clinical application value.
作者
郑文丽
林慧娟
丁国明
邵飞飞
罗金明
ZHENG Wenli;LIN Huijuan;DING Guoming;SHAO Feifei;LUO Jinming(Department of Critical Care,Taizhou First People's Hospital,Taizhou 318000,Zhejiang,China;Department of Outpatient,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou 3178000,Zhejiang,China;Department of Nephrology,Taizhou First People's Hospital,Taizhou 318000,Zhejiang,China)
出处
《中国现代医生》
2023年第2期57-60,共4页
China Modern Doctor
基金
浙江省市县级科技计划项目(21ywb48)。
关键词
脓毒症
低分子肝素
凝血功能
炎症指标
免疫功能
Sepsis
Low molecular weight heparin
Coagulation function
Inflammatory index
Immunity
