摘要
[目的]探讨经尿道膀胱肿瘤切除术(TURBT)联合化疗治疗T2期肌层浸润性膀胱癌的临床疗效及其对血清Dickkopf蛋白(DKK)、蛋白磷酸酶2A的癌性抑制因子(CIP2A)水平的影响.[方法]回顾性分析2018年1月至2021年1月本院收治的130例T 2期肌层浸润性膀胱癌(MIBC)患者临床资料,根据治疗方法的不同分为观察组(采用TURBT手术方案联合化疗治疗,n=75)和对照组[采用开放根治性膀胱切除术(ORC)治疗,n=55].记录两组患者手术时间、术中出血量、术后留置导管时间及手术并发症发生情况,比较两组患者手术前后血清DKK、CIP2A水平.[结果]观察组患者术中出血量、手术时间及留置导尿管时间均少于对照组,差异有统计学意义(P<0.05).术后,两组血清CEA、CA19-9、CA125水平均低于术前,且观察组低于对照组,差异有统计学意义(P<0.05);两组血清DKK、CIP2A水平均低于术前,且观察组低于对照组,差异有统计学意义(P<0.05).观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05).观察组复发率与对照组比较,差异无统计学意义(P>0.05).[结论]相较于ORC治疗,采用TURBT对膀胱癌患者治疗后可显著提高临床疗效,并降低血清DKK、CIP2A水平,且创伤更小.
【Objective】To investigate the clinical efficacy of transurethral resection of bladder tumor(TURBT)combined with chemotherapy in the treatment of T2 myometrial invasive bladder cancer and the influence on the levels of serum Dickkopf protein(DKK)and cancerous inhibitor of protein phosphatase 2A(CIP2A).【Methods】The clinical data of 130 patients with T2 myometrial invasive bladder cancer(MIBC)admitted to our hospital from January 2018 to January 2021 were retrospectively analyzed.According to the different treatment methods,they were divided into the observation group(treated with TURBT combined with chemotherapy,n=75)and the control group treated with open radical cystectomy(ORC,n=55).The operation time,intraoperative blood loss,postoperative catheter indwelling time and surgical complications of the two groups were recorded,and the serum DKK and CIP2A levels of the two groups were compared before and after operation.【Results】The bleeding volume,operation time and indwelling catheter time in the observation group were significantly lower than those in the control group(P<0.05).After operation,the levels of serum CEA,CA19-9 and CA125 in the two groups were lower than those before operation,and the levels in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05);The levels of serum DKK and CIP2A in the two groups were lower than those before operation,and those in the observation group were lower than those in the control group,with significant difference(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,with a statistically significant difference(P<0.05).There was no significant difference in the recurrence rate between the observation group and the control group(P>0.05).【Conclusion】Compared with ORC operation,TURBT operation can significantly improve the clinical efficacy of bladder cancer patients,reduce the serum DKK and CIP2A levels,and have less trauma.
作者
周克斌
林佳伟
赵留存
ZHOU Ke-bin;LIN Jia-wei;ZHAO Liu-cun(Department of Urology,Xi'an Ninth Hospital,Xi'an Shaanxi 710054)
出处
《医学临床研究》
CAS
2023年第1期61-63,67,共4页
Journal of Clinical Research
