摘要
金黄色葡萄球菌是常见的引起医院感染和社区感染的致病菌之一。近年来,临床上金黄色葡萄球菌抗感染治疗失败的病例越来越多,生物被膜的形成被认为是导致抗菌药物治疗失败的主要原因。然而,金黄色葡萄球菌生物被膜的耐药机制并未完全阐明。证据表明,金黄色葡萄球菌生物被膜感染难以治愈且容易反复,感染后反复治疗将大大增加患者的痛苦和经济负担。本文对金黄色葡萄球菌生物被膜耐药机制的研究进展进行综述,以期为开发新的抗菌药物提供参考依据。
Staphylococcus aureus(S.aureus)is one of the common pathogens causing healthcare-associated infection(HAI)and community-associated infection(CAI).In recent years,there are more and more failure cases in the anti-infection treatment of S.aureus in clinical practice,and the formation of biofilm is considered the main cause for the failure of antimicrobial treatment.However,drug resistance mechanism of S.aureus biofilm has not been fully elucidated.Evidence shows that S.aureus biofilm infection is difficult to cure and easy to reoccur,and repea-ted treatment after infection greatly increases the pain and economic burden of patients.In this paper,research progress of drug resistance mechanism of S.aureus biofilm is reviewed,so as to provide reference for the development of new antimicrobial agents.
作者
曾建业
陈丹丹
王俣棋
吕纯莉
王小敏
ZENG Jian-ye;CHEN Dan-dan;WANG Yu-qi;LYU Chun-li;WANG Xiao-min(Department of Microbiology,Zunyi Medical University,Zunyi 563000,China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2023年第2期244-248,共5页
Chinese Journal of Infection Control
基金
国家自然科学基金项目(32260883)
贵州省科技计划项目(黔科合平台人才[2018]5772-005)。
