摘要
目的探究激素合用复方磺胺甲唑对中重度缺氧艾滋病伴肺孢子菌肺炎患者的临床效果分析。方法方便选择扬州市第三人民医院2018年7月—2021年7月收治的中重度缺氧艾滋病伴肺孢子菌肺炎患者86例为研究对象,并以随机抽签的方法将其均分为两组,每组43例,对照组单用复方磺胺甲唑治疗,研究组采取激素合用复方磺胺甲唑进行治疗,对比两组临床疗效。结果研究组治疗总体有效率高于对照组(95.35%vs 76.74%),差异有统计学意义(χ^(2)=6.198,P<0.05)。治疗7 d后以及14 d后研究组动脉血氧分压(PaO_(2))、动脉二氧化碳分压(PaCO_(2))和血氧饱和度(SaO_(2))水平分别为(68.62±7.84)mmHg和(80.03±8.97)mmHg、(25.98±2.47)mmHg和(20.09±2.84)mmHg以及(91.77±4.26)%和(94.80±4.51)%,均优于对照组,差异有统计学意义(t=5.057、4.816、9.309、10.795、4.150、4.174,P<0.05)。研究组不良反应发生率低于对照组(13.95%vs 16.28%),但差异无统计学意义(χ^(2)=0.091,P>0.05)。结论在中重度缺氧艾滋病伴肺孢子菌肺炎患者的临床治疗中采用激素合用复方磺胺甲唑的效果更为理想,能够有效改善患者临床症状和血气指标,且不良反应较少,安全性高。
Objective To explore the clinical effect of hormone combined with compound sulfamethazole on moderate to severe hypoxia AIDS patients with Pneumocystis pneumonia.Methods 86 patients with moderate to severe hypoxia AIDS with Pneumocystis pneumonia admitted to Yangzhou Third People’s Hospital from July 2018 to July 2021 were conveniently selected as the research object.They were divided into two groups by random drawing,43 cases in each group,the control group treated with compound sulfamethazole alone,and the study group treated with hormone combined with compound sulfamethazole.The clinical curative effects of the two groups were compared.Results The overall effective rate of treatment in the study group was higher than that in the control group(95.35%vs 76.74%),and the difference was statistically significant(χ^(2)=6.198,P<0.05).The levels of arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))and blood oxygen saturation(SaO_(2))in the study group were(68.62±7.84)mmHg and(80.03±8.97)mmHg,(25.98±2.47)mmHg and(20.09±2.84)mmHg,(91.77±4.26)%and(94.80±4.51)%,which were better than the control group,respectively,the difference was statistically significant(t=5.057,4.816,9.309,10.795,4.150,4.174,P<0.05).The adverse reaction rate in the study group was lower than that in the control group(13.95 vs 16.28%),but the difference was not statistically significant(χ^(2)=0.091,P>0.05).Conclusion In the clinical treatment of moderate and severe hypoxia AIDS patients with Pneumocystis pneumonia,it is more effective to use hormones combined with compound sulfamethoxazole,which can effectively improve the clinical symptoms and blood gas indexes of patients,with less adverse reactions,high safety.
作者
王靖
李文颖
WANG Jing;LI Wenying(Department of Infectious Diseases,the Third People´s Hospital of Yangzhou,Yangzhou,Jiangsu Province,225001 China;Department of Hepatology,Yangzhou Third People´s Hospital,Yangzhou,Jiangsu Province,225001 China)
出处
《中外医疗》
2022年第28期132-135,145,共5页
China & Foreign Medical Treatment
关键词
艾滋病
肺孢子菌肺炎
激素
复方磺胺甲唑
不良反应
AIDS
Pneumocystis pneumonia
Hormones
Compound sulfamethoxazole
Adverse reactions
