摘要
目的:观察知柏地黄丸加减方熏洗联合盐酸舍曲林片治疗老年阴虚火旺型失眠症的疗效。方法:选取126例老年阴虚火旺型失眠症患者,随机分成2组各63例,2组均给予盐酸舍曲林片治疗,试验组加用知柏地黄丸加减方熏洗治疗,2组均治疗4周。治疗前后应用匹兹堡睡眠质量指数(PSQI)及过度觉醒量表(HAS)评价2组患者的睡眠质量,检测5-羟色胺(5-HT)、多巴胺(DA)及炎症因子[白细胞介素-1β (IL-1β)、肿瘤坏死因子-α (TNF-α)]。比较2组的疗效,观察4周内的治疗安全性。结果:治疗4周,试验组临床疗效总有效率为92.06%,高于对照组的77.78%,差异有统计学意义(P<0.05)。2组PSQI评分、HAS评分均较治疗前降低,试验组PSQI评分、HAS评分均低于对照组,差异均有统计学意义(P<0.01)。2组血清5-HT水平均较治疗前升高,血清DA、IL-1β、TNF-α水平均较治疗前降低,差异均有统计学意义(P<0.01)。试验组血清5-HT水平高于对照组,血清DA、IL-1β、TNF-α水平均低于对照组,差异均有统计学意义(P<0.01)。2组患者在治疗期间均未发生明显不良反应。结论:知柏地黄丸加减方熏洗联合盐酸舍曲林片治疗老年阴虚火旺型失眠症患者效果确切,能够提高患者的睡眠质量,安全性良好。
Objective:To observe the curative effect of fumigation and washing with modified Zhibai Dihuang Pills combined with Sertraline Hydrochloride Tablets for senile insomnia of vigorous fire due to yin deficiency type. Methods:A total of 126 cases of senile patients with insomnia of vigorous fire due to yin deficiency type were selected and randomly divided into two groups,with 63 cases in each group. Both groups were treated with Sertraline Hydrochloride Tablets,and the trial group was additionally treated with fumigation and washing with modified Zhibai Dihuang Pills. Both groups were treated for four weeks.Before and after treatment, the sleep quality of patients in the two groups was evaluated by Pittsburgh Sleep Quality Index(PSQI) and Hyperarousal Scale(HAS);5-hydroxytryptamine(5-HT),dopamine(DA) and inflammatory factors including interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) were detected.The curative effects in the two groups were compared,and the safety during four-week treatment was observed. Results:After four weeks of treatment,the total effective rate was 92.06% in the trial group,higher than that of 77.78% in the control group,the difference being significant(P<0.05). The scores of PSQI and HAS in the two groups were decreased when compared with those before treatment,and the scores of PSQI and HAS in the trial group were lower than those in the control group,differences being significant(P<0.01). The levels of serum 5-HT in the two groups were increased when compared with those before treatment,and the levels of DA,IL-1β and TNF-α in serum were decreased,differences being significant(P<0.01). The level of serum 5-HT in the trial group was higher than that in the control group,and the levels of DA,IL-1β and TNF-α in serum were lower,differences being significant(P<0.01). During the treatment,there was no obvious adverse reaction in the two groups. Conclusion:The therapy of fumigation and washing with modified Zhibai Dihuang Pills combined with Sertraline Hydrochloride Tablets for senile patients with insomnia of vigorous fire due to yin deficiency type has a definite effect,and can improve the sleep quality of patients with good safety.
作者
郑文燕
余颖
ZHENG Wenyan;YU Ying
出处
《新中医》
CAS
2022年第24期59-63,共5页
New Chinese Medicine
关键词
失眠症
阴虚火旺证
知柏地黄丸
中药熏洗
炎症因子
睡眠质量
Insomnia
Vigorous fire due to yin deficiency syndrome
Zhibai Dihuang Pills
Chinese herbal fumigation and washing
Inflammatory factors
Sleep quality
