摘要
目的分析β2-微球蛋白(β2-microglobulin,β2-MG)与超敏C反应蛋白(hypersensitive C-reactive pro-tein,hs-CRP)在早期2型糖尿病肾病(Type 2 diabetic nephropathy,T2DN)中的临床意义。方法回顾性分析2021年1—12月三明市中西医结合医院检验科收治的170例2型糖尿病患者临床资料,根据尿微量白蛋白检测率(microalbuminuria,m Alb)将其分为早期T2DN组(m Alb在30~300mg/g)75例与单纯2型糖尿病组(m Alb<30mg/g)95例。两组均接受血β2-MG与hs-CRP检测,比较两组β2-MG与hs-CRP水平,以及β2-MG、hs-CRP与β2-MG联合hs-CRP对于早期T2DN检测的敏感度与特异度。同时,针对早期T2DN患者hs-CRP、β2-MG表达与m Alb的相关性进行分析。结果早期T2DN组β2-MG与hs-CRP指标均高于单纯2型糖尿病组,差异有统计学意义(P<0.05)。β2-MG联合hs-CRP对早期T2DN检测的敏感度与特异度均高于单纯β2-MG、hs-CRP检测,差异有统计学意义(P<0.05);β2-MG与hs-CRP对早期T2DN检测的敏感度与特异度对比,差异无统计学意义(P>0.05)。采用Spearman相关性分析显示,早期T2DN组患者β2-MG、hs-CRP表达与m Alb呈正相关性(P<0.05)。结论β2-MG与hs-CRP在早期T2DN检测中具有一定的应用意义,且联合检测的价值更高,为后续临床诊疗工作提供了重要的参考指标。
Objective To analyze the clinical significance ofβ2-microglobulin(β2-MG)and hypersensitive C-reactive protein(hs-CRP)in early type 2 diabetic nephropathy(T2DN).Methods The clinical data of 170 patients with type 2 diabetes admitted to the clinical laboratory of Sanming Hospital of Integrated Traditional Chinese and Western Medicine from January to December 2021 were retrospectively analyzed.They were divided into 75 cases in the early T2DN group(m Alb 30-300 mg/g)and 95 cases in the pure type 2 diabetes group(m Alb<30 mg/g)according to the urine microalbumin detection rate(microalbuminuria,m Alb).Both groups received bloodβ2-MG and hs-CRP tests.The sensitivity and specificity ofβ2-MG and hs-CRP levels,as well asβ2-MG,hs-CRP andβ2-MG com-bined with hs-CRP for the detection of early T2DN were compared between the two groups.Meanwhile,the correla-tion between hs-CRP andβ2-MG expression and m Alb was analyzed for patients with early T2DN.Results The in-dexes ofβ2-MG and hs-CRP were higher in the early T2DN group than in the type 2 diabetes group alone,the differ-ence was statistically significant(P<0.05).The sensitivity and specificity ofβ2-MG combined with hs-CRP for the de-tection of early T2DN were higher than those ofβ2-MG and hs-CRP alone,the difference was statistically significant(P<0.05).There was no statistically significant difference seen in the results(P>0.05).Data correlation analysis using Spearman showed that the expression ofβ2-MG and hs-CRP were positively correlated with m Alb in the early T2DN group(P<0.05).Conclusionβ2-MG and hs-CRP have certain application significance in the detection of early T2DN.And the value of the combined test is higher,which provides an important reference index for the subsequent clinical diagnosis and treatment.
作者
江凌
路宁娜
邹清娥
JIANG Ling;LU Ningna;ZOU Qing'e(Department of Laboratory,Sanming Hospital of Integrative Medicine,Sanming,Fujian Province,365000 China)
出处
《糖尿病新世界》
2022年第23期181-183,187,共4页
Diabetes New World Magazine
