摘要
目的:系统评价厚朴三物汤对临床腹部手术后胃肠道功能恢复的临床疗效。方法:检索中国知网(CNKI)、维普数据库(VIP)、中国生物医学文献服务系统(SinoMed)、万方数据资源库(Wangfang Data)、Pubmed、Embase、Cochrane Library数据库,检索时限均从建库至2021年1月,收集所有关于厚朴三物汤对临床腹部手术后胃肠道功能恢复的随机对照临床试验(RCT)文献。由两位研究者独立筛选文献、提取数据并评估纳入研究的偏倚风险。采用RevMan 5.3软件进行Meta分析。结果:共纳入15项RCT,共计1242例受试者。Meta分析结果显示:与对照组相比,厚朴三物汤能显著提高胃肠道恢复的总有效率[OR=3.54,95%CI(2.43,5.14),P<0.01],明显缩短腹部手术后病人的平均肛门排气时间[SMD=-1.88,95%CI(-2.75,-1.02),P<0.01]、首次排便时间[SMD=-3.77,95%CI(-5.54,-2.00),P<0.01]和肠鸣音恢复时间[SMD=-2.19,95%CI(-3.56,-0.82),P<0.01]。结论:厚朴三物汤对腹部手术后胃肠道功能的恢复具有明显促进作用。
Objective:To evaluate the effect of Houpu Sanwu Decoction on the recovery of gastrointestinal function of patients after abdominal surgery.Methods:The databases CNKI,VIP,SinoMed,Wangfang Data,Pubmed,Embase and Cochrane Library were searched to collect randomized controlled trials(RCTs)of Houpu Sanwu Decoction for the recovery of gastrointestinal function of patients after abdominal surgery from the establishment to January 2021.Two researchers screened the literature,extracted data and assessed risk of bias of included studies independently.RevMan 5.3 was utilized for Meta-analysis.Results:A total of 15 RCTs with 1242 subjects were included in the Meta analysis.The results showed that Houpu Sanwu Decoction improved the total effective rate of gastrointestinal recovery[OR=3.54,95%CI(2.43,5.14),P<0.01],and shortened the mean anal exhaust time[SMD=-1.88,95%CI(-2.75,-1.02),P<0.01],time of first defecation[SMD=-3.77,95%CI(-5.54,-2.00),P<0.01]and recovery time of bowel sound[SMD=-2.19,95%CI(-3.56,-0.82),P<0.01].Conclusion:Houpu Sanwu Decoction promoted the recovery of gastrointestinal function of patients after abdominal surgery.
作者
刘思雨
周玮玲
刘芳
石金凤
崔星
刘绍瑒
Liu Siyu;Zhou Weilin;Liu Fang;Shi Jinfeng;Cui Xing;Liu Shaoyang(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137)
出处
《中药药理与临床》
CAS
CSCD
北大核心
2022年第6期155-159,共5页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家自然基金青年基金项目(编号:81603300)
中国博士后科学基金面上项目(编号:2020M673569XB)
四川省科技厅项目(编号:20YYJC0655)
成都中医药大学杏林学者计划(编号:QNXZ2018006)。
关键词
厚朴三物汤
腹部手术
胃肠道功能恢复
META分析
Houpu Sanwu Decoction(厚朴三物汤)
abdominal surgery
recovery of gastrointestinal function
Meta-analysis
