摘要
目的分析Solitaire血管重建装置(Solitaire FR)支架机械介入取栓术联合溶栓治疗急性脑梗死(ACI)的临床效果。方法抽取2019年2月至2021年11月濮阳市安阳地区医院收治的87例ACI患者为研究对象,按照治疗方式分为对照组(43例)和观察组(44例)。对照组采用溶栓治疗,观察组采用Solitaire FR支架机械介入取栓术联合溶栓治疗。比较两组的临床效果、脑血流速度、美国国立卫生院卒中量表(NIHSS)评分、血清神经功能因子[骨桥蛋白(PON)、氨基末端脑钠肽前体(NT-proBNP)]、血清细胞因子[血管性血友病因子(vWF)、内皮素-1(ET-1)、基质金属蛋白酶-9(MMP-9)]水平。结果观察组总有效率(95.45%,42/44)高于对照组(79.07%,34/43),P<0.05。治疗后,观察组脑中动脉、脑前动脉血流速度均高于对照组(P均<0.05);治疗后7、14 d,观察组NIHSS评分均低于对照组(P均<0.05);治疗后,观察组PON、NT-proBNP、vWF、ET-1、MMP-9水平均低于对照组(P均<0.05)。结论Solitaire FR支架机械介入取栓术联合溶栓治疗ACI患者,可促进血管再通,改善脑血流速度,并可调节血清细胞因子和神经功能因子表达,减轻神经功能缺损。
Objective To analyze the clinical effect of Solitaire vascular reconstruction device(Solitaire FR)stent mechanical interventional thrombectomy combined with thrombolysis in the treatment of acute cerebral infarction(ACI).Methods Eighty-seven patients with ACI treated in Anyang District Hospital of Puyang from February 2019 to November 2021 were selected as the research subjects.According to the treatment methods,they were divided into control group(43 cases)and observation group(44 cases).Patients in the control group received thrombolysis,and patients in the observation group received Solitaire FR stent mechanical interventional thrombectomy combined with thrombolysis.The clinical effects,cerebral blood flow velocity,the National Institutes of Health Stroke Scale(NIHSS)score,serum neurological function factors including osteopontin(PON),N-terminal pro brain natriuretic peptide(NT-proBNP),and serum cytokines including von Willebrand factor(vWF),endothelin-1(ET-1)and matrix metalloproteinase-9(MMP-9)were compared between the two groups.Results The total effective rate of the observation group was 95.45%(42/44),which was higher than 79.07%(34/43)of the control group(P<0.05).After treatment,the blood flow velocity of middle cerebral artery and anterior cerebral artery in the observation group were higher than those in the control group(all P<0.05).The NIHSS score of the observation group was lower than that of the control group 7 d and 14 d after treatment(all P<0.05).After treatment,the levels of PON,NT-proBNP,vWF,ET-1 and MMP-9 in the observation group were lower than those in the control group(all P<0.05).Conclusions Solitaire FR stent mechanical interventional thrombectomy combined with thrombolysis in the treatment of ACI can promote vascular recanalization,improve cerebral blood flow velocity,regulate the expression of serum cytokines and neurological function factors,and reduce neurological deficits.
作者
李建波
杨玉峰
刘聪
郭芳莉
Li Jianbo;Yang Yufeng;Liu Cong;Guo Fangli(Department of Neurology,Anyang District Hospital of Puyang,Anyang 455000,China)
出处
《中国实用医刊》
2022年第21期15-18,共4页
Chinese Journal of Practical Medicine
