摘要
自噬是细胞内溶酶体参与的降解受损细胞器或大分子物质的过程,生理状态下真核细胞通过较低程度的自噬维持组织内稳态平衡。近年来多项研究显示自噬参与缺血、缺氧等所致疾病的病理生理过程。丙泊酚作为常用的静脉麻醉药,广泛应用于各类手术中,研究表明丙泊酚通过抑制缺血/再灌注、缺氧/复氧等诱导的自噬性细胞死亡发挥保护作用,同时也有研究表明丙泊酚可激活自噬进而发挥抗肿瘤作用。目前关于丙泊酚调控自噬的研究涉及AMPK/mTOR、Bcl/Beclin、Ca^(2+)、miRNA等多种细胞信号通路,本文基于最新研究就丙泊酚调控自噬的相关机制作一综述。
Autophagy is a process in which intracellular lysosomes are involved in the degradation of damaged organelles or macromolecular substances.In the physiological state,eukaryotic cells maintain tissue homeostasis through a low degree of autophagy.In recent years,many studies have shown that autophagy is involved in the pathophysiological disease processes caused by ischemia and hypoxia.As a commonly used intravenous anesthetic,propofol is widely used in various types of surgery.Recent studies have shown that propofol plays a protective role by inhibiting autophagic cell death induced by ischemia/reperfusion and hypoxia/reoxygenation.Meanwhile,other studies have shown that propofol can activate autophagy and have an anti-tumor effect.Current studies on the regulation of autophagy by propofol,involve AMPK/mTOR,Bcl/Beclin,Ca^(2+),miRNA and other cell signaling pathways.Based on the latest research,this paper reviews the mechanisms of propofol regulation of autophagy.
作者
张晓爽
杨丽丽
解雅英
Xiao-Shuang ZHANG;Li-Li YANG;Ya-Ying XIE(Graduate School of Inner Mongolia Medical University,Hohhot 010030,China;Department of Anesthesiology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China)
出处
《医学新知》
CAS
2023年第1期68-73,共6页
New Medicine
基金
内蒙古自治区卫生健康委卫生健康科技计划项目(20201265)。
