摘要
目的:探讨ABO基因rs507666和rs651007多态性及相应的遗传风险评分(GRS)与河南农村汉族人群2型糖尿病(T2DM)患病风险之间的关系。方法:基于“河南农村队列”的基线调查,共纳入648名T2DM病例,按照同性别、年龄±3岁的原则进行1∶1匹配获得648名对照。采用SNPscan®技术对ABO基因rs507666和rs651007进行基因分型。采用条件Logistic回归模型分析ABO基因多态性与T2DM之间的关系。构建3种GRS(简单相加GRS、基于条件Logistic回归的GRS和可释方差GRS)评估其与T2DM患病风险的关联。结果:调整协变量后,相对于基因型GG,rs507666的基因型AA与T2DM的OR(95%CI)为1.794(1.044~3.082);相对于基因型CC,rs651007的基因型TT与T2DM的OR(95%CI)为1.858(1.083~3.185)。rs507666和rs651007的3种GRS与T2DM关联的OR(95%CI)分别为1.109(1.005~1.224)、1.083(1.004~1.168)和1.171(1.007~1.360)。结论:河南农村汉族人群ABO基因rs507666的A等位基因和rs651007的T等位基因及其3种GRS与T2DM患病风险相关。
Aim:To investigate the association of rs507666 and rs651007 of ABO gene polymorphism and the corresponding genetic risk score(GRS) with type 2 diabetes mellitus(T2DM) risk. Methods: A total of 648 T2DM cases from the baseline survey of Henan Rural Cohort were included,and 648 controls were matched according to gender,age ± 3 years. The genotypes of ABO gene polymorphisms were achieved by SNPscan®technology. Conditional Logistic regression model was used to explore association of ABO gene polymorphisms with T2DM risk. Moreover,three GRS methods(SC-GRS,DL-GRS and EV-GRS) were applied. Results: After adjusting for covariates,compared with the genotype GG,the estimated effect[OR(95% CI) ]of genotype AA of the rs507666 locus on T2DM risk was 1. 794(1. 044-3. 082);compared with the genotype CC,the estimated effect[OR(95% CI) ] of genotype TT of the rs651007 locus was 1. 858(1. 083-3. 185). The OR( 95% CI) for the associations of three GRS with T2DM risk were 1. 109(1. 005-1. 224),1. 083(1. 004-1. 168) and 1. 171(1. 007-1. 360),respectively. Conclusion: A allele of rs507666 and T allele of rs651007 of ABO gene as well as three corresponding GRS are associated with the risk of T2DM prevalence in Han population from Henan rural area.
作者
何亚玲
刘晓田
郑旖铨
常高华
侯建
霍文倩
毛振兴
王重建
HE Yaling;LIU Xiaotian;ZHENG Yiquan;CHANG Gaohua;HOU Jian;HUO Wenqian;MAO Zhenxing;WANG Chongjian(Department of Epidemiology,College of Public Health,Zhengzhou University,Zhengzhou 450001;Department of Environmental Health,College of Public Health,Zhengzhou University,Zhengzhou 450001)
出处
《郑州大学学报（医学版）》
CAS
北大核心
2023年第1期45-49,共5页
Journal of Zhengzhou University(Medical Sciences)
基金
国家自然科学基金项目(82003543,81602925)
河南省高校科技创新团队支持计划项目(21IRTSTHN029)
河南省高校重点科研项目(21A330007)。
