摘要
肺纤维化是一种不可逆的肺间质组织异质性疾病,主要病理特征为成纤维细胞异常增殖以及细胞外基质过度沉积。目前,抗纤维化治疗还没有特效药,而许多天然产物已显示出对肺纤维化疾病的潜在治疗作用。而多靶点、不良反应较小的优势使天然产物抗肺纤维化成为近年来的研究热点。通过整理国内外近5年相关文献,综述了天然产物通过抑制炎症反应、降低氧化应激、调整细胞自噬等途径发挥抗肺纤维化作用的机制。
Pulmonary fibrosis is an irreversible heterogeneous disease of lung interstitial tissue.The main pathological features are abnormal proliferation of fibroblasts and excessive deposition of extracellular matrix.At present,there is no specific drug for anti-fibrosis treatment,but many natural products have potential therapeutic effects on pulmonary fibrosis disease.In addition,the advantages of multiple targets and small adverse reactions make natural products anti-pulmonary fibrosis become a research hotspot in recent years.This paper reviewed the mechanism of natural products’anti-pulmonary fibrosis effect through inhibiting inflammatory response,reducing oxidative stress and regulating autophagy by reviewing domestic and foreign literature in recent five years.
作者
陈丽
王占黎
王素华
靳敏
CHEN Li;WANG Zhanli;WANG Suhua;JIN Min(School of Public Health,Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou O14040,Inner Mongolia,China;Inner Mongolia Key Laboratory of Disease-Related Biomarkers,Baotou 014040,Inner Mongolia,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第1期171-174,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81860575)
内蒙古自治区科技创新引导项目(CXYD2021BT02)
包头医学院科研专项博士启动基金项目(BYJJ-BSJJ202008)。
关键词
天然产物
抗肺纤维化
信号通路
机制
natural products
pulmonary fibrosis
signaling pathways
mechanisms
