摘要
目的考察小续命汤结合常规治疗大面积脑梗死后脑水肿的临床效果。方法随机选取2018年1月—2020年1月医院收治的大面积脑梗死后脑水肿患者90例,患者被随机分为实验组和对照组,每组45例。对照组接受常规治疗,实验组接受常规治疗+小续命汤治疗,连续治疗14 d。治疗后,采用ELISA法测定血清S-100β、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)水平,NIHSS评估患者神经功能缺损程度,采用BORN-BE无创脑水肿动态监护仪监测各组脑水肿变化情况(脑水肿扰动吸收),颅脑CT观测梗死灶周围低密度容量。结果实验组明显改善率和总有效率显著高于对照组(χ^(2)=4.727,P<0.05;χ^(2)=8.459,P<0.01);实验组第7天和第14天梗死灶周围低密度容积大小显著低于对照组(t=3.134,P<0.01;t=7.067,P<0.01),实验组第7天和第14天脑颅内压显著低于对照组(t=5.576,P<0.01;t=3.971,P<0.01);治疗后,实验组S-100β、NSE、MBP和NIHSS显著低于对照组(t=8.050,P<0.01;t=10.463,P<0.01;t=5.700,P<0.01;t=8.341,P<0.01)。结论小续命汤结合常规治疗可缓解大面积脑梗死后脑水肿程度,保护神经功能,值得临床推广使用。
Objective To investigate the clinical effect of Xiaoxuming Decoction(小续命汤)combined with conventional treatment on brain edema after massive cerebral infarction.Methods Ninety patients with cerebral edema after massive cerebral infarction in the hospital from January 2018 to January 2020 were selected and randomly divided into experimental group and control group,45 cases in each group.The control group received conventional treatment,and the experimental group received conventional treatment+Xiaoxuming Decoction.After treatment,the levels of serum S-100β,neuron specific enolase(NSE)and myelin basic protein(MBP)were measured by ELISA.National Institute of Health Stroke Scale(NIHSS)was used to evaluate the degree of neurological deficit.Born-be non-invasive brain edema dynamic monitor was used to monitor the changes of brain edema(disturbance absorption of brain edema)in each group.Brain CT was used to observe the low-density volume around the infarct.Results The improvement rate and total effective rate of the experimental group were significantly higher than those of the control group(χ^(2)=4.727,P<0.05;χ^(2)=8.459,P<0.01);the low density volume around the infarct in the experimental group was significantly lower than that of the control group on the 7th and 14th day(t=3.134,P<0.01;t=7.067,P<0.01);the intracranial pressure of the experimental group was significantly lower than that of the control group on the 7th and 14th day(t=5.576,P<0.01;t=3.971,P<0.01).After treatment,the levels of S-100β,NSE and MBP and NIHSS scores in the experimental group were significantly lower than those in the control group(t=8.050,P<0.01;t=10.463,P<0.01;t=5.700,P<0.01;t=8.341,P<0.01).Conclusion Xiaoxuming Decoction combined with conventional treatment can alleviate the degree of brain edema after massive cerebral infarction and protect nerve function,which is worthy of clinical application.
作者
赵光峰
刘德浪
许玉皎
王家艳
王君
ZHAO Guangfeng;LIU Delang;XU Yujiao;WANG Jiayan;WANG Jun(Hainan Provincial Hospital of Traditional Chinese Medicine,Haikou 570203,Hainan,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第1期179-182,共4页
Chinese Archives of Traditional Chinese Medicine
基金
海南省自然科学基金项目(817344)。
关键词
小续命汤
大面积脑梗死
脑水肿
脑扰动系数
Xiaoxuming Decoction(小续命汤)
large area cerebral infarction
brain edema
brain disturbance coefficient
