摘要
盐酸纳布啡是一种新型的阿片类镇痛药,对阿片受体κ呈激动作用,因而可发挥强效镇痛作用,尤其对内脏疼痛效果较佳;对μ受体呈部分拮抗作用,使其在发挥镇痛作用的同时可部分拮抗μ受体相关的呼吸抑制、皮肤瘙痒、恶心呕吐等不良反应。正因为纳布啡特殊的作用机制,以及较少的不良反应,使纳布啡在围手术期有着广阔的应用前景。该文就纳布啡在围手术期应用的研究进展进行综述,以期为临床合理用药提供理论参考和实践依据。
Naborphine hydrochloride is a new opioid analgesic,which stimulates theκ-opioid receptor,so it can play a powerful analgesic role,especially for visceral pain.Naborphine partially antagonizes theμ-opioid receptor so that it can partially antagonize the adverse reactions related to theμ-opioid receptor,such as respiratory inhibition,nausea,vomiting,skin itching and other adverse effects,while exerting analgesic effect.It is because of the special mechanism of action and fewer adverse reactions of nablorphine that it has broad application prospect in perioperative period.This article reviewed the research progress of the application of nablorphine in perioperative period,in order to provide theoretical reference and practical basis for rational drug use.
作者
金红利(综述)
赵秀梅(审校)
JIN Hongli;ZHAO Xiumei(Department of Anesthesiology,Chongqing Jiulongpo District People's Hospital,Chongqing 400050,China)
出处
《现代医药卫生》
2023年第4期657-662,共6页
Journal of Modern Medicine & Health
关键词
纳布啡
阿片类镇痛药
围手术期
综述
Naborphine
Opioid analgesics
Peroperative period
Review
