摘要
目的分析针对应用早卵泡期长方案治疗体外受精/卵胞浆内单精子注射(IVF/ICSI)治疗的不孕症患者,在不同时期添加重组促黄体生成素(r-LH)对患者助孕结局的影响。方法选取170例行早卵泡期长效长方案促排卵治疗IVF/ICSI,日血清促黄体生成素(LH)<0.5 IU/L患者,根据在促性腺激素(Gn)治疗后患者应用r-LH时期不同分为对照组(50例)、研究Ⅰ组(40例)、研究Ⅱ组(40例)、研究Ⅲ组(40例)。对照组不添加r-LH,研究I组卵泡发育早期添加r-LH,研究Ⅱ组卵泡发育中期添加r-LH,研究Ⅲ组卵泡发育晚期添加r-LH。比较四组患者启动日超排卵相关数据及助孕结局。结果研究Ⅰ组人绒毛膜促性腺激素(HCG)日雌二醇(E_(2))水平最高,且与对照组比较,差异有统计学意义(P<0.05);研究Ⅰ组启动日LH水平最低,与余下三组比较差异有统计学意义(P<0.05);HCG日LH水平比较,研究Ⅰ组数值最低,研究Ⅱ组数值最高,两组比较差异有统计学意义(P<0.05);四组间两两子宫内膜厚度、获卵数比较差异无统计学意义(P>0.05);研究Ⅰ组LH量最多,比较差异有统计学意义(P<0.05)。四组移植胚胎数比较,差异无统计学意义(P>0.05);研究Ⅱ组2PN受精率最高,但与余下三组数据比较,差异无统计学意义(P>0.05);研究Ⅰ组、研究Ⅱ组、研究Ⅲ组临床妊娠率均高于对照组,且研究Ⅱ组临床妊娠率最高,差异有统计学意义(P<0.05);研究Ⅰ组早期妊娠丢失率最高,与余下三组比较差异有统计学意义(P<0.05)。对照组优质胚胎率最低,且与研究Ⅰ组、研究Ⅱ组、研究Ⅲ组比较差异有统计学意义(P<0.05)。结论针对低LH患者,应用r-LH治疗可获得较高的优质胚胎率。同时利于临床妊娠率及种植率的提升,在卵泡发育中晚期添加r-LH可利于妊娠结局的提升。
Objective To analyze the effects of addition of recombinant luteinizing hormone(r-LH)at difFerent times on pregnation-assisted outcomes in infertile patients treated with in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)with long early follicular stage regimen.Methods A total of 170 patients who underwent early follicular stage long-acting regimen of ovulation induction treatment IVF/ICSI and daily serum luteinizing hormone(LH)<0.5 IU/L were selected.The patients were divided into control group(50 cases),study group I(40 cases),study group II(40 cases)and study group HI(40 cases)according to the different periods of application of recombinant luteinizing hormone(r-LH)after gonadin(Gn)treatment.In the control group,r-LH was not added.r-LH was added in the early stage of follicular development in study group I,in the middle stage of follicular development in study group II,and in the late stage of follicular development in study group DI.The data related to superovulation on the starting day and assisted pregnancy outcome were compared among the four groups.Results The estradiol(E_(2))level of human chorionic gonadotropin(HCG)day in study group I was the highest,and the difference was statistically significant compared with control group(P<0.05).The level of LH in group I was the lowest on starting day,and the difference was statistically significant compared with the other three groups(P<0.05).The LH level on HCG day was the lowest in study group I and the highest in study group II, and the difference between the two groups was statistically significant (P<0.05). There were no significant differences in endometrial thickness and egg number among the four groups (P>0.05). The amount of LH in study group I was the highest, and the difference was statistically significant (P<0.05). There was no significant difference in the number of transplanted embryos among the four groups (P>0.05). The 2PN fertilization rate of study group II was the highest, but there was no statistical significance compared with the other three groups (P>0.05). The clinical pregnancy rate of study group I , study group II and study group III was higher than that of control group, and study group II had the highest clinical pregnancy rate, the difference was statistically significant (P<0.05). Study group I had the highest rate of early pregnancy loss, and the difTerence was statistically significant compared with the other three groups (P<0.05). The rate of high-quality embryos in control group was the lowest, and the difference was statistically significant compared with study groups I , II and III (P<0.05). Conclusion For patients with low LH, r-LH treatment can obtain a higher quality embryo rate. At the same time, it is beneficial to improve the clinical pregnancy rate and implantation rate, and the addition of r-LH in the middle and late stage of follicular development can improve the pregnancy outcome.
作者
曾晓霞
Zeng Xiaoxia(Reproductive Center,Shantou Central Hospital,Shantou 515031,China)
出处
《实用妇科内分泌电子杂志》
2022年第24期44-47,共4页
Electronic Journal of Practical Gynecological Endocrinology
基金
汕头市科学技术局项目(编号191221225263323)。
关键词
体外受精
不同时期
重组促黄体生成素
启动日
低血清
妊娠结局
In vitro fertilization
Different periods
Recombinant luteinizing hormone
The date of commencement
Hyposerum
Pregnancy outcome
