摘要
目的探讨睡眠时相提前综合征(advanced sleep phase syndrome,ASPS)和2型糖尿病(type 2 diabetes mellitus,T2DM)间的关联性,为深入理解睡眠的健康效应及预防和干预T2DM提供理论依据。方法本研究数据来源于美国国家健康和营养调查(National Health and Nutrition Examination Survey,NHANES)(2017―2018年)数据库。ASPS由工作日的就寝时间和晨起时间定义。T2DM根据服用降糖药物来定义。使用基于倾向性评分的逆概率加权法(inverse probability treatment weight,IPTW)和重叠加权法(overlap weights,OW)尽可能地控制潜在混杂变量后,分析ASPS和T2DM的关联性。结果共有6048名研究对象被纳入研究,其中759人患有T2DM,411人被诊断为ASPS,分别占12.5%、6.8%。T2DM在ASPS组中的患病率比非ASPS组高(20.0%vs.12.0%,t=21.295,P<0.001)。IPTW控制潜在混杂后,分析显示ASPS组患T2DM的风险是非ASPS组的1.540倍(OR=1.540,95%CI:1.184~2.002,P=0.001);OW进一步完全均衡协变量后,分析显示二者差异有统计学意义(OR=1.362,95%CI:1.078~1.722,P=0.001)。结论ASPS是T2DM独立风险因素,提示睡眠问题的管理在T2DM的防制中具有重要意义。
Objective This study aimed to analyze the correlation between advanced sleep phase syndrome(ASPS)and type 2 diabetes mellitus(T2DM),to better understand the health effects of sleep and provide a theoretical basis for prevention and intervention of T2DM.Methods The data for this study were obtained from the National Health and Nutrition Examination Survey(NHANES)(2017-2018)database.ASPS was defined by bedtime and morning rise time on weekdays.T2DM was defined as taking antidiabetic drugs.Associations between ASPS and T2DM were analyzed using the propensity score-based inverse probability treatment weights(IPTW)and overlap weights(OW)to control for potential confounding variables as much as possible.Results A total of 6048 participants were included in the study,of whom 759 had T2DM and 411 were diagnosed with ASPS,accounting for 12.5%and 6.8%,respectively.The prevalence of T2DM was higher in the ASPS group than in the non-ASPS group(20.0%vs.12.0%,t=21.295,P<0.001).After controlling for potential confounding by IPTW,the analysis showed that the ASPS group had a 1.540-fold higher risk of developing T2DM than the non-ASPS group(OR=1.540,95%CI:1.184-2.002,P=0.001).After further fully balancing the covariates,OW analysis showed the significance of the two still existed(OR=1.362,95%CI:1.078-1.722,P=0.001).Conclusions ASPS is an independent risk factor for T2DM,suggesting that the management of sleep problems is of great significance in the prevention and treatment of T2DM.
作者
高绒绒
高倩
王彤
GAO Rong-rong;GAO Qian;WANG Tong(Department of Health Statistics,School of Public Health,Shanxi Medical University,Taiyuan 030001,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2023年第1期53-59,共7页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(82073674)
山西省科技重大专项项目(202102130501003,202005D121008)。
关键词
睡眠时相提前综合征
2型糖尿病
逆概率加权
重叠加权
Advanced sleep phase syndrome
Type 2 diabetes
Inverse probability weighting
Overlap weighting
