摘要
目的探讨血清趋化素样因子-1(CKLF-1)、环氧化酶-2(COX-2)水平对支气管哮喘患儿临床分型的评估价值。方法选取川北医学院附属医院儿科2019年9月至2020年9月收治的支气管哮喘患儿102例作为疾病组,另于同期选取90例健康体检儿童作为健康组。两组均采集静脉血进行血清CKLF-1、COX-2水平检测并对比。另以痰液嗜酸性粒细胞(EOS%)≥2%为标准将支气管哮喘患儿分为嗜酸细胞性哮喘(EA)和非嗜酸细胞性哮喘(NEA)2个亚型,对比2个亚型的年龄、性别、病程、肺功能1秒率和血清CKLF-1、COX-2水平,并采用受试者工作特征(ROC)曲线分析血清CKLF-1、COX-2水平对支气管哮喘患儿EA型的评估价值。结果疾病组血清CKLF-1、COX-2水平明显高于健康组(P<0.05);结果显示102例支气管哮喘患儿中EA型为52例,占总数的50.98%,NEA型为50例,占总数的49.02%;EA型的年龄、性别、病程、肺功能1秒率与NEA型比较差异均无统计学意义(P>0.05),EA型的血清CKLF-1、COX-2水平均高于NEA型(P<0.05);ROC曲线分析结果显示血清CKLF-1与COX-2水平联合评估支气管哮喘临床EA型的灵敏度和曲线下面积(AUC)分别为94.23%、0.958,均高于单独评估(P<0.05),联合评估特异度(92.00%)与单独评估对比差异均无统计学意义(P>0.05)。结论血清CKLF-1、COX-2水平均对支气管哮喘患儿临床分型具有一定的评估价值,但二者联合评估效能更高。
Objective To investigate the evaluation value of serum levels of chemokine like factor-1(CKLF-1)and cyclooxygenase-2(COX-2)in the clinical classification of children with bronchial asthma.Methods 102 children with bronchial asthma treated in pediatrics of Affiliated Hospital of North Sichuan Medical College from September 2019 to September 2020 were selected as the disease group,and 90 healthy children were selected as the healthy group in the same period.Venous blood were collected from both groups,and the levels of serum CKLF-1 and COX-2 were detected and compared.According to eosinophil(EOS%)of sputum≥2%,children with bronchial asthma were divided into eosinophilic asthma(EA)and non-eosinophilic asthma(NEA),and the age,sex,course of disease,one second rate of pulmonary function and serum levels of CKLF-1 and COX-2 were compared,and the evaluation value of serum CKLF-1 and COX-2 levels in EA type of children with bronchial asthma was analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum CKLF-1 and COX-2 in the disease group were significantly higher than those in the healthy group(P<0.05).The results showed that among 102 children with bronchial asthma,there were 52 cases of EA type,accounting for 50.98%of the total,and 50 cases of NEA type,accounting for 49.02%of the total.There was no significant difference in age,sex,course of disease and one second rate of pulmonary function between EA type and NEA type(P>0.05),but the serum levels of CKLF-1 and COX-2 in EA type were higher than those in NEA type(P<0.05).ROC curve analysis showed that the sensitivity and area under curve(AUC)of serum levels of CKLF-1 and COX-2 in the combination evaluation of EA type of bronchial asthma were 94.23%and 0.958 respectively,which were higher than those of single evaluation(P<0.05),but the joint evaluation specificity(92.00%)had no significant difference compared with single evaluation(P>0.05).Conclusion The levels of serum CKLF-1 and COX-2 have a certain evaluation value on the differentiation of clinical types of children with bronchial asthma,but the combined evaluation efficiency of the two is higher.
作者
谷志勇
刘一波
GU Zhiyong;LIU Yibo(Department of Pediatrics,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China;Department of Pediatrics,Nanchong Fourth People′s Hospital,Nanchong,Sichuan 637000,China)
出处
《国际检验医学杂志》
CAS
2023年第4期446-449,共4页
International Journal of Laboratory Medicine
基金
四川省医学科研青年创新课题(Q20009)。
