摘要
目的 探究祛瘀消膜汤联合黄体酮胶囊治疗药物流产不全患者的效果。方法 选取2020年10月至2021年10月于秦皇岛市中医医院治疗的120例药物流产不全患者作为研究对象,采取随机数字表法分为探究组和参照组,各60例。给予探究组患者祛瘀消膜汤联合黄体酮胶囊治疗,给予参照组患者黄体酮胶囊治疗。治疗前后检测两组可溶性FMS样酪氨酸激酶1(sFlt-1)、血管内皮生长因子(VEGF)、人绒毛膜促性腺激素(HCG)、孕酮(P)、雌激素(E2)、γ-干扰素(IFN-γ)、白介素-2(IL-2)水平,记录两组阴道出血时间、转经时间、行清宫手术例数。结果 探究组VEGF水平低于参照组(P<0.05),sFlt-1、E2水平高于参照组(P<0.05),P、HCG、IFN-γ水平低于参照组(P<0.05),IL-2水平高于参照组(P<0.05);探究组阴道出血时间、转经时间短于参照组(P<0.05),清宫术人数少于参照组(P<0.05);探究组总有效率(98.33%)高于参照组(86.67%)(P<0.05)。结论 祛瘀消膜汤联合黄体酮胶囊治疗药物流产不全患者,可提升sFlt-1水平,降低VEGF水平,改善性激素指标,抑制机体炎症,提升患者临床疗效。
Objective To observe the effect of Quyu Xiaomo Decoction combined with progesterone capsules on patients with incomplete medical abortion.Methods A total of 120 patients with incomplete medical abortion who were treated in Qinhuangdao Hospital of Traditional Chinese Medicine from October 2020 to October 2021 were selected and divided into the research group and the reference group by random number table method, with 60 patients in each group.. 60 patients in the research group were treated with Quyu Xiaomo Decoction combined with progesterone capsules, 60 patients in reference group was treated with progesterone capsules, and the soluble FMS-like tyrosine kinase 1(sFlt-1), vascular endothelial growth factor(VEGF), human chorionic gonadotropin(HCG), progesterone(P), estrogen(E2), γ-interferon(IFN-γ), and interleukin-2(IL-2) levels were tested before and after treatment in the two groups, and the vaginal bleeding time, menstrual transition time, and the number of cases of hysterectomy in the two groups were recorded. Results The level of VEGF in the research group was lower than that in the reference group(P<0.05), the level of sFlt-1、E2in the research group was higher than that in the reference group(P<0.05). The level of P、HCG、IFN-γ in the research group was lower than that in the reference group(P<0.05), the level of IL-2 in the research group was higher than that in the reference group(P<0.05). The elapsed time was shorter than that of the reference group(P<0.05), the number of patients undergoing uterine evacuation in the research group was less than that in the reference group(P<0.05), and the total effective rate of patients in the research group(98.33%) was higher than that in the reference group(86.67%)(P<0.05).Conclusions Quyu Xiaomo Decoction combined with progesterone capsules in the treatment of patients with incomplete medical abortion can increase the level of sFlt-1, reduce the level of VEGF, improve sex hormone indicators, inhibit inflammation in the body, and improve the clinical efficacy of patients.
作者
陈小欢
佟明铭
陈佳
吴芳
孙晓吉
杨冬梅
CHEN Xiaohuan;TONG Mingming;CHEN Jia;WU Fang;SUN Xiaoji;YANG Dongmei(Qinhuangdao Hospital of Traditional Chinese Medicine,Qinhuangdao 066000,Hebei,China)
出处
《中国性科学》
2023年第2期136-140,共5页
Chinese Journal of Human Sexuality
基金
河北省秦皇岛市科学技术研究与发展计划(202101A198)
河北省中医药科研计划(2022086)。
