摘要
肠道是人体最大的免疫器官,肠道内定植的各肠道菌群彼此制衡,相依相辅,与宿主构成互利共生的关系,其数量及种类改变可造成肠道微生态失衡,并通过免疫调节的方式影响机体免疫功能,进而影响疾病进展。目前研究发现,肠道微生态与风湿免疫性疾病如系统性红斑狼疮、强直性脊柱炎、痛风性关节炎、类风湿关节炎等密切相关,而以肠道菌群作为切入点探索痛风的发病机制成为新的研究热点。本文从肠道微生态的组成及功能,痛风患者肠道菌群的结构特点,肠道菌群在痛风发病中的作用机制,以及益生菌、中药和粪便微生物移植治疗等方面进行综述,旨在为痛风的防治提供新的思路和方向。
Intestinal tract is the largest immune organ of human body where hundreds of millions of microorganisms are colonized which are called intestinal flora.Each intestinal flora checks and balances each other,depends on and complements each other,and forms a mutually beneficial symbiotic relationship with the host.Changes in quantity and type of intestinal flora will cause the imbalance of intestinal microecology,affect the systemic immune function through immune regulation,and then affect the progress of the disease.At present,it has been found that intestinal microecology is closely related to rheumatic immune diseases such as systemic lupus erythematosus,ankylosing spondylitis,gouty arthritis and rheumatoid arthritis.Taking intestinal flora as the starting point to explore the pathogenesis of gout has become a new research hotspot.Based on the current research,the relevant literature was consulted in present paper,and the intestinal microecological composition and function,the structural characteristics of intestinal flora in patients with gout,the mechanism of intestinal flora in the pathogenesis of gout,and the treatment of probiotics,traditional Chinese medicine and fecal microbial transplantation were reviewed,in order to provide new ideas and directions for prevention and treatment of gout in the future.
作者
章晓云
李华南
李时斌
王伟伟
陈锋
甘斌
刘永钱
Zhang Xiao-Yun;Li Hua-Nan;Li Shi-Bin;Wang Wei-Wei;Chen Feng;Gan Bin;Liu Yong-Qian(Clinical Medical College of Jiangxi University of Chinese Medicine,Nanchang,Jiangxi 330004,China;Department of Orthopedics,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning,Guangxi 530011,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2023年第1期97-106,共10页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金(81860857,82060871)
江西省自然科学基金(20202BAB206071)
江西省教育厅科学技术研究项目(GJJ190582)
江西省中医药管理局科技计划项目(2020B0333)
江西省邓运明国医名师工作室建设项目(赣中医药综合字[2021]12号)。
关键词
肠道菌群
肠道微生态
痛风
嘌呤
发病机制
intestinal flora
intestinal microecology
gout
purine
pathogenesis
