摘要
糖尿病肾病(DN)是糖尿病最严重的微血管并发症,也是糖尿病最常见和最严重的并发症之一,是世界范围内终末期肾病的主要原因,是糖尿病患者发病和死亡的主要原因,也是全球最大的非传染性死亡原因。皂苷类化合物种类众多,是许多中草药的主要生物活性成分,具有降血糖、降脂、改善胰岛素抵抗、抗炎、抗氧化应激、抗肿瘤、调节免疫等多种药理活性。近些年来,许多实验研究显示,中药皂苷类活性成分调控DN疗效明确。中药皂苷干预糖尿病肾病具有多靶点、多信号通路、多系统、多效应的特点和作用。在防治DN上具有广阔前景。目前体内外关于中药皂苷类成分干预DN的研究众多,但是缺乏系统的、全面的对中药皂苷类成分干预DN的研究的整理、概括、综述,所以对近年来国内外关于中药皂苷类干预DN模型的实验研究进行总结,对其通过改善糖脂代谢、抑制氧化应激、抗炎、抗细胞凋亡、调节自噬、抗纤维化、保护足细胞等途径缓解DN的机制进行阐述,以期为DN相关防治药物的研发提供思路和参考。
Diabetic nephropathy(DN), the most feared microvascular complication of diabetes and one of the most common and serious complications of diabetes, is the major cause of end-stage renal disease worldwide, leading cause of morbidity and mortality in patients with diabetes, and the main non-communicable cause of death worldwide. There are many types of saponins, which are the main bioactive components of various Chinese medicinals. They have various pharmacological activities such as lowering blood glucose and blood lipids, improving insulin resistance, anti-inflammation, anti-oxidative stress, anti-tumor, and immune modulation. In recent years, it has been frequently verified that the saponins in Chinese medicinals have definite effect in regulating DN, showing multi-target, multi-pathway, multi-system, multi-effect characteristics. Thus, they have broad prospects in the prevention and treatment of this disease. There has been an explosion of research on the treatment of DN with saponins in Chinese medicinals in vivo and in vitro, but there is a lack of systematic and comprehensive summary. Therefore, this study summed up the studies of saponins in Chinese medicinals in the intervention of DN and summarized the mechanisms such as improving glucolipid metabolism, inhibiting oxidative stress, anti-inflammation, anti-apoptosis, regulating autophagy, anti-fibrosis, and protecting podocytes, with a view to providing ideas and references for the development of drugs related to DN.
作者
杨鹏
刘铜华
吴丽丽
秦灵灵
张程斐
彭川
张秋娥
YANG Peng;LIU Tonghua;WU Lili;QIN Lingling;ZHANG Chengfei;PENG Chuan;ZHANG Qiue(The First Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712046,China;Key Laboratory of Chinese Medicine and Health Sciences,Ministry of Education,Beijing University of Chinese Medicine,Beijing 100029,China;Chengdu University of Chinese Medicine,Chengdu 610075,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第4期263-271,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
科技部中医药防治糖尿病国际联合研究中心(国家级国际联合研究中心)项目(2015B01022)
北京市中医药防治糖尿病国际科技合作基地项目
教育部中医药防治糖尿病及其并发症创新引智基地项目(B20055)。
关键词
中药皂苷
糖尿病肾病
信号通路:作用机制
saponins in Chinese medicinals
diabetic nephropathy
signaling pathway:mechanism
