摘要
目的:分析双歧杆菌四联活菌片辅助治疗肝硬化并发细菌性腹膜炎的临床价值。方法:选取2019年3月—2021年3月收治的肝硬化并发细菌性腹膜炎患者68例,按照随机数字表法分为对照组和观察组,每组34例。对照组接受常规抗感染治疗,观察组在对照组基础上联合双歧杆菌四联活菌片,对比两组治疗效果、炎症指标及肝功能指标的变化。结果:观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗后观察组白细胞(WBC)、C-反应蛋白(CRP)、降钙素原(PCT)、中性粒细胞计数及CD64指数均低于对照组,差异有统计学意义(P<0.05);治疗后观察组谷丙转氨酶(ALT)、谷草转氨酶(AST)及总胆红素(TBIL)均低于对照组,血清白蛋白(ALB)高于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率对比,差异无统计学意义(P>0.05)。结论:双歧杆菌四联活菌片联合常规抗感染治疗肝硬化并发细菌性腹膜炎效果显著,可有效降低患者体内炎症水平,改善患者肝功能。
Objective: To analyze the clinical value of bifidobacterium quadruple viable tablets adjuvant therapy on liver cirrhosis with bacterial peritonitis.Methods: Totally 68 patients with liver cirrhosis complicated with bacterial peritonitis who were treated in the hospital were enrolled between March 2019 and March 2021 and were divided into control group and observation group according to the random number method, with 34 cases in each group.Control group received standard anti-infective therapy, and observation group was combined with bifidobacterium quadruple viable tablets on the basis of control group.The treatment effect, inflammatory indicators and liver function indicators were compared between the two groups.Results: The effective rate of treatment in observation group was higher than that in control group(P<0.05).After treatment, the levels of white blood cell(WBC),C-reactive protein(CRP),procalcitonin(PCT),neutrophil count and CD64 index in observation group were lower than those in control group(P<0.05).After treatment, the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST) and total bilirubin(TBIL) were lower in observation group than those in control group while the level of serum albumin(ALB) was higher than that in control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion: Bifidobacterium quadruple viable tablets combined with standard anti-infective therapy has a significant effect on liver cirrhosis with bacterial peritonitis.It can effectively reduce the body’s inflammation level and improve the liver function of patients.
作者
杨冬冬
YANG Dongdong(The First Peoples Hospital of Ruzhou,Ruzhou 467599,China)
出处
《临床医药实践》
2023年第3期182-185,共4页
Proceeding of Clinical Medicine
关键词
肝硬化并发细菌性腹膜炎
双歧杆菌四联活菌片
标准抗感染治疗
临床疗效
liver cirrhosis with bacterial peritonitis
bifidobacterium quadruple viable tablets
standard anti-infective therapy
clinical efficacy
