摘要
目的:采用病例对照研究的方法,观察鼻咽部感染与小儿肠系膜淋巴结肿大的关系,探讨肠系膜淋巴结肿大与鼻咽部感染的临床相关性。方法:选取2019年10月—2021年5月黑龙江中医药大学附属第一医院儿科门诊及病房经超声诊查为肠系膜淋巴结肿大的166例患儿作为研究对象,选取同一时期诊断为慢性胃炎的63例患儿。分别统计合并鼻咽部感染的患儿的数量,对研究对象进行单因素和多因素logistic回归分析。结果:两组患儿组内性别、年龄比较均无统计学意义(P=0.309 6)。流黄涕≥10 d (P=0.000)、咽充血/不适(P=0.000)、恶心(P=0.000)、鼻后滴流(P=0.002)、颈淋巴结肿大(P=0.000)、OSAHS(P=0.000)与小儿肠系膜淋巴结肿大相关;经多因素logistic回归分析,调整混杂因素得出流黄涕≥10 d(P=0.000)、咽充血/不适(P=0.000)、鼻后滴流(P=0.000)、颈淋巴结肿大(P=0.000)、OSAHS (P=0.000)是小儿肠系膜淋巴结肿大发生的相关危险因素,恶心(P=0.929)不是小儿肠系膜淋巴结肿大发生的相关危险因素。结论:鼻咽部慢性感染与肠系膜淋巴结肿大具有显著相关性,但机制尚不清楚,有待进一步研究讨论。
Objective:A case-control study was used to observe the relationship between nasopharyngeal infection and pediatric mesenteric lymph node enlargement and to investigate the clinical correlation between mesenteric lymph node enlargement and nasopharyngeal infection.Methods:166 children diagnosed with mesenteric lymph node enlargement by ultrasound in the pediatric outpatient clinic and ward of the hospital from October 2019 to May 2021 were selected for the study, and 63 children diagnosed with chronic gastritis in the same period were selected. The number of children with combined nasopharyngeal infections was counted separately, and univariate and multivariate logistic regression analyses were performed on the study population.Results:There was no statistically significant difference between the two groups of children in terms of gender and age within the group(P=0.309 6). Runny yellow nose for≥10 d(P=0.000), pharyngeal congestion/discomfort(P=0.000), nausea(P=0.000), postnasal drip(P=0.002), cervical lymph node enlargement(P=0.000), and OSAHS(P=0.000) were associated with pediatric mesenteric lymph node enlargement. Multifactorial logistic regression analysis revealed that adjusting for confounders yielded yellow runny nose ≥10d(P=0.000), pharyngeal congestion/discomfort(P=0.000), postnasal drip(P=0.000), cervical lymph node enlargement(P=0.000),and OSAHS(P=0.000) were risk factors associated with the development of pediatric mesenteric lymph node enlargement, and nausea(P=0.929) was not a risk factor associated with the development of pediatric mesenteric lymphadenopathy.Conclusion:Chronic nasopharyngeal infection is significantly associated with mesenteric lymph node enlargement, but the mechanism is unclear and needs to be discussed in further studies.
作者
杜玉晗
王海
DU Yu-han;WANG Hai(Heilongjiang University of Traditional Chinese Medicine,Harbin,Heilongjiang,150040,China)
出处
《黑龙江医学》
2023年第3期276-279,共4页
Heilongjiang Medical Journal
关键词
肠系膜淋巴结肿大
慢性鼻咽部感染
儿童
肠-肺轴
Mesenteric lymphadenopathy
Chronic nasopharyngeal infection
Children
Gut-lung axis
