摘要
目的研究血清25-羟维生素D水平与脑小血管病(CSVD)所致的血管性认知障碍(VCI)的相关性。方法选取2020年5月至2021年7月湛江中心人民医院神经内一科收治的CSVD患者200例为研究对象,按照认知功能将患者分为无认知障碍的对照组和有认知障碍的病例组,每组各100例。检测两组患者血清25-羟维生素D水平,采用Pearson分析其水平与VCI的关系,多因素logistics回归分析导致VCI的危险因素。结果两组患者年龄、性别、吸烟、饮酒比较,差异无统计学意义(P>0.05);与病例组比较,对照组患者发生高血压、糖尿病、心脑血管病史的人数较少(P<0.05)。与病例组比较,对照组血清25-羟维生素D、钙、磷及高密度脂蛋白胆固醇的水平较高,而碱性磷酸酶、低密度脂蛋白胆固醇及三酰甘油水平较低(P<0.05)。高血压、糖尿病、心脑血管病史、血清25-羟维生素D、钙、磷、碱性磷酸酶、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、三酰甘油为VCI的危险因素,有糖尿病、高血压及心脑血管病史的患者血清25-羟维生素D水平低。血清25-羟维生素D含量随着VCI程度的加重而呈下降趋势(P<0.05)。血清25-羟维生素D与VCI呈负相关(R=-0.869,P=0.000)。结论血清25-羟维生素D水平随CSVD所致的VCI加重而下降,可作为预测CSVD所致的VCI的指标。
Objective To study the correlation between serum 25-hydroxyvitamin D level and vascular cognitive impairment(VCI)caused by cerebral small vessel disease(CSVD).Methods A total of 200 patients with CSVD who were admitted to the DepartmentⅠof Neurology,Central People’s Hospital of Zhanjiang from May 2020 to July 2021 were selected as the study objects.By cognitive function,the patients were divided into the control group(without cognitive impairment)and the case group(with cognitive impairment),with 100 cases in each group.Serum 25-hydroxyvitamin D levels in the two groups were detected,and the relationship between serum 25-hydroxyvitamin D level and VCI was analyzed by Pearson’s method.Multi-factor logistics regression analysis was adopted to analyze the risk factors leading to VCI.Results There were no significant differences in age,gender,smoking and drinking between the two groups(P>0.05).The number of patients with history of hypertension,diabetes and cardiovascular and cerebrovascular diseases in the control group is less than that in the case group(P<0.05).Compared with the case group,the control group had higher levels of serum 25-hydroxyvitamin D,calcium,phosphorus and high-density lipoprotein cholesterol,and lower levels of alkaline phosphatase,low-density lipoprotein and triglyceride(P<0.05).History of hypertension,diabetes,and cardiovascular and cerebrovascular diseases,serum 25-hydroxyvitamin D,calcium,phosphorus,alkaline phosphatase,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,and triglyceride were risk factors for VCI.Patients with history of diabetes,hypertension,and cardiovascular and cerebrovascular diseases had lower serum 25-hydroxyvitamin D level.Serum 25-hydroxyvitamin D level tended to decrease with the aggravation of VCI(P<0.05).Serum 25-hydroxyvitamin D was negatively correlated with VCI(R=-0.869,P=0.000).Conclusion Since serum 25-hydroxyvitamin D level decreases with the aggravation of VCI caused by CSVD,it can be used as an index to predict VCI caused by CSVD.
作者
李新鸿
陈明祝
杨伟超
唐龙冲
LI Xinhong;CHEN Mingzhu;YANG Weichao;TANG Longchong(DepartmentⅠof Neurology,Central People’s Hospital of Zhanjiang,Guangdong,Zhanjiang 524000,China)
出处
《中国医药科学》
2023年第4期8-11,82,共5页
China Medicine And Pharmacy
基金
广东省湛江市科技计划项目(2020B01112)。
关键词
血清25-羟维生素D
脑小血管病
血管性认知障碍
相关性
Serum 25-hydroxyvitamin D
Cerebral small vessel disease
Vascular cognitive impairment
Correlation
