摘要
目的:探讨前列地尔联合不同剂量鼠神经生长因子在糖尿病周围神经病变(DPN)中的应用及对运动和感觉神经传导、炎性反应因子水平的影响。方法:选取2018年6月至2020年3月北海市人民医院收治的150例DPN患者,按随机数字表法分为低剂量组、高剂量组,各75例。在常规治疗基础上,低剂量组给予前列地尔+鼠神经生长因子18μg/次,1次/d;高剂量组给予前列地尔+鼠神经生长因子30μg/次,1次/d,两组均治疗3周,比较两组的疗效,治疗前及治疗1、3周后运动和感觉神经传导速度和肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)水平,并进行成本-效果分析,记录两组不良反应发生情况。结果:两组总有效率比较差异无统计学意义(P>0.05)。两组治疗1、3周后运动和感觉神经传导速度及TNF-α、IL-6、hs-CRP、WBC水平比较差异无统计学意义(P>0.05)。低剂量组每取得一个单位效果的成本为43.11元,低于高剂量组的57.58元,并且每增加一个单位效果,高剂量组比低剂量组多付出572.56元。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论:前列地尔联合18μg鼠神经生长因子治疗DPN,对临床症状、运动和感觉神经传导、炎性反应因子的改善效果与30μg相似,且在成本-效果方面具有优势。
Objective To investigate the application of alprostadil combined with different doses of mouse nerve growth factor in diabetic peripheral neuropathy(DPN)and its effect on motor and sensory nerve conduction and inflammatory factors.Methods One hundred and fiftypatients with DPN treated in Beihai People′s Hospital from June 2018 to March 2020 were randomly divided into low-dose group and high-dose group,with 75 cases in each group.On the basis of routine treatment,the low-dose group was given alprostadil+mouse nerve growth factor 18μg/time,once a day.The high-dose group was given alprostadil+mouse nerve growth factor 30μg/time,once a day,both two groups were treated for 3 weeks.The curative effect,motor and sensory nerve conduction velocity and inflammatory index tumor necrosis factor-α(TNF-α)interleukin-6(IL-6),high sensitivity C-reactive protein(hs-CRP),white blood cell count(WBC)and cost-effectiveness analysis,adverse reactions between the two groups were compared.Results There was no significant difference in the total effective rate between the low dose group and the high dose group(P>0.05).After 1 and 3 weeks of treatment,the levels ofmotor and sensory nerve conduction velocity and TNF-α,IL-6,hs-CRP and WBC in the two groups has no significant differences(P>0.05).The cost of each unit effect in the low-dose group was 43.11 Yuan,and the cost of each unit effect in the high-dose group was 57.58 Yuan.The high-dose group was higher than that in the low-dose group,and the high-dose group paid 572.56 Yuan more than the low-dose group for each additional unit effect.There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Alprostadil combined with 18μg mouse nerve growth factor in the treatment of DPN has a similar improvement effect on clinical symptoms,motor and sensory nerve conduction and inflammatory factors,and has advantages in cost-effectiveness.
作者
王寒啸
林爱萍
Wang Hanxiao;Lin Aiping(Department of Endocrinology,Beihai People′s Hospital,Beihai 536000,China)
出处
《中国医师进修杂志》
2023年第2期136-140,共5页
Chinese Journal of Postgraduates of Medicine
