摘要
皮肤附属器毛囊作为药物输送的新靶点和新途径受到诸多关注,经皮渗透毛囊靶向递药系统的设计与开发对毛囊源性皮肤病如痤疮、脱发及毛囊炎等发挥直接高效的作用。本综述围绕毛囊的结构和生理功能、毛囊微环境、影响毛囊渗透的因素、纳米制剂促进经毛囊渗透的现状及表征毛囊靶向渗透的技术进行归纳,并系统总结了毛囊靶向递药系统治疗痤疮和脱发的最新研究进展。最后,探讨了毛囊靶向给药系统设计当前所面临的挑战。本综述可为毛囊源性皮肤病毛囊靶向给药系统设计提供思路与参考。
Hair follicle(HF),one of the skin appendages,has received a lot of attention to be a new target and pathway for drug delivery.The development of hair follicle targeted drug delivery system(HFTDDS) through percutaneous permeation is particularly important for skin diseases derived from HF such as acne,hair loss,and folliculitis for their on-site action.This review describes the structure and physiological function of HF,the microenvironment of HF,and factors affecting HF permeation.Multiple nanoformulations used to improve the HF permeation and technologies to characterize the HF permeation were introduced.The latest advance of HFTDDS based on nanoformulations were systematically summarized and analyzed in the treatment of acne and hair loss.Finally,the challenges of formulating HFTDDS were discussed.The review is expected to provide some ideas and references for developing delivery systems for treating skin diseases derived from HF.
作者
熊莎
刘紫艺
肖婷
徐月红
XIONG Sha;LIU Zi-yi;XIAO Ting;XU Yue-hong(School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China)
出处
《药学学报》
CAS
CSCD
北大核心
2023年第1期95-105,共11页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81973491)
广东省基础与应用基础研究基金(2022A1515010428)。
关键词
毛囊靶向
痤疮
脱发
纳米递药系统
经皮渗透
hair follicle targeted
acne
hair loss
nano-based drug delivery system
percutaneous permeation
