摘要
目的系统评价在手足口病治疗中热毒宁注射液联合干扰素的有效性和安全性。方法计算机检索PubMed、the Cochrane Library、EMbase、CNKI、VIP、WanFang Data和CBM数据库,纳入有关热毒宁注射液联合干扰素治疗小儿手足口病的随机对照试验,从数据库建库时间起至2022年10月31日设置为检索时限。采用Revman 5.3软件进行Meta分析。结果共计纳入11项研究,合计1190例患者。结果显示,热毒宁联合干扰素治疗小儿手足口的临床有效率优于单用干扰素〔OR=6.67,95%CI(4.10,10.87),P<0.00001〕;热毒宁联合组患儿的口腔溃疡痊愈时间、体温恢复正常时间、疱疹消失时间及住院时间明显短于单用干扰素(P<0.001);治疗后,热毒宁联合组患儿的心肌酶谱(肌酸激酶、肌酸激酶同工酶MB、低密度脂蛋白)和谷丙转氨酶水平均明显低于单用干扰素组(P<0.05)。两组不良反应均较少,且差异无统计学显著性。结论热毒宁注射液联合干扰素治疗手足口病是安全、有效的,但亟需更多高质量的临床试验加以验证。
Objective To evaluate the efficacy and safety of Reduning injection combined with interferons in the treatment of hand foot mouth disease(HFMD).Methods PubMed,Cochrane Library,EMbase,CNKI,VIP,Wanfang,and CBM database were searched for randomized controlled trials about Reduning injection combined with interferons in the treatment of HFMD that were published from inception to October 31,2022.Meta analyses were performed using RevMan 5.3 software.Results A total of 11 studies involving 1190 patients were included.The results showed that the effective rate of drug combinations was significantly higher than that of interferons used alone〔OR=6.67,95%CI(4.10,10.87),P<0.00001〕.Fever,herpes and oral ulcer healed in less time in children treated with Reduning combined with interferons than in those treated with interferons alone(P<0.001).After treatment,indexes of the myocardial enzyme spectrum(creatine kinase,creatine kinase MB and low density lipoprotein)and alanine aminotransferase in the Reduning combined with interferon group were all significantly lower than those of the interferon alone group(P<0.05).There were relatively few adverse reactions in both groups.Conclusion Reduning injection combined with interferons in the treatment of HFMD is safe and effective,but this approach needs to be verified by more high-quality clinical trials.
作者
周嫏嬛
宋颂
孙孚春
龚伟玲
ZHOU Lang-huan;SONG Song;SUN Fu-chun;GONG Wei-ling(People's Hospital of Chengyang District,Qingdao 266109,China;Administration for Drug and Instrument Supervision and Inspection of PLAJLSF,Beijing 100166,China)
出处
《解放军药学学报》
CAS
2023年第1期77-82,共6页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
手足口病
儿童
热毒宁注射液
干扰素
META分析
hand foot mouth disease
children
Reduning injection
interferon
Meta analysis
