摘要
胰岛移植在糖尿病及其并发症的治疗中有很广阔的前景,但移植后功能不良、排斥反应和供体不足等是胰岛移植领域的瓶颈。优化胰腺保存方法对获取有效胰岛的数量及功能的维护有积极意义;在培养期间对胰岛进行抗排斥反应和抗凋亡处理,包括间充质干细胞(MSC)、MSC来源的外泌体、抗凋亡药物和基因修饰等可能成为临床胰岛移植胰岛保护与功能维护的重要方法;胰岛移植后抗立即经血液介导的炎症反应(IBMIR)药物的使用对于胰岛功能的保护也具有重要作用。本文围绕从胰岛制备到胰岛移植的全过程,探讨胰岛保护和功能维护相关策略,旨在为提升供体质量以弥补供体绝对数量的不足,提升胰岛移植效率提供参考。
Islet transplantation is a promising treatment of diabetes mellitus and its complications.Nevertheless,dysfunction post-transplantation,rejection and shortage of donors are the bottleneck issues in the field of islet transplantation.Optimizing the preservation method of pancreas plays a positive role in obtaining a sufficient quantity of effective islets and maintaining their functions.During the culture stage,anti-rejection and anti-apoptosis treatment of islets,including mesenchymal stem cell(MSC),MSC-derived exosomes,anti-apoptosis drugs and gene modification,may become major approaches for islet protection and functional maintenance in clinical islet transplantation.Use of anti-instant blood-mediated inflammatory reaction(IBMIR)drugs after islet transplantation also plays a critical role in protecting islet function.In this article,the whole process from islet preparation to islet transplantation was illustrated,and relevant strategies of islet protection and functional maintenance were reviewed,aiming to provide reference for improving the quality of donors to compensate for the shortage of absolute quantity of donors and elevating the efficiency of islet transplantation.
作者
高宏君
邱敏华
陈继冰
Gao Hongjun;Qiu Minhua;Chen Jibing(Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Guangxi Clinical Medical Research Center for Renal Diseases of Integrated Chinese and Western Medicine,Nanning 530011,China;不详)
出处
《器官移植》
CAS
CSCD
北大核心
2023年第2期207-212,共6页
Organ Transplantation
基金
广西科技基地和人才专项(桂科AD22035122)。
