摘要
目的 探讨母体血清基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、胎盘生长因子(plasma placental growth factor, PLGF)联合乳酸脱氢酶(lactate dehydrogenase, LDH)对重度子痫前期不良妊娠结局的预测价值。方法 选取2018年12月到2020年1月在南京医科大学附属常州妇幼保健院住院分娩的80例妊娠期高血压疾病患者作为研究对象,将其分为重度子痫前期组(n=34)和子痫前期组(n=46),另取同期40例正常孕妇作为对照组,测量3组孕妇血清MMP-9、PLGF、LDH指标情况,对比3组孕妇的妊娠结局。将34例重度子痫前期患者根据妊娠结局分为不良妊娠结局组(n=10)和良好妊娠结局组(n=24),对比两组患者的基本资料与血清MMP-9、PLGF、LDH指标,并分析血清MMP-9、PLGF联合LDH对重度子痫前期不良妊娠结局的预测价值。结果 3组孕妇血清MMP-9、PLGF、LDH指标差异有统计学意义(P<0.05);重度子痫前期组患者不良妊娠结局发生率为32.35%,子痫前期组为8.70%,对照组为2.50%,差异有统计学意义(P<0.05);不良妊娠结局组与良好妊娠结局组年龄、体质量指数差异无统计学意义(P>0.05),血清MMP-9、PLGF、LDH指标差异有统计学意义(P<0.05);对单因素分析具有统计学差异的指标进行赋值:MMP-9≤0.32为1,>0.32为0;PLGF≤0.80为1,>0.80为0;体质量指数≥23.4为1,<23.4为0;LDH≥363.23为1,<363.23为0;年龄≥28为1,<28为0。MMP-9、PLGF、LDH均是导致重度子痫前期患者发生不良妊娠结局的影响因素(P<0.05)。结论 患者母体血清MMP-9、PLGF能够作为重度子痫前期的不良结局预测因素,MMP-9、PLGF联合LDH对重度子痫前期不良妊娠结局的预测价值更高,可以为临床诊断与治疗提供参考。
Objective To investigate the predictive value of matrix metalloproteinase-9(MMP-9)and plasma placental growth factor(PLGF),combined with lactate dehydrogenase(LDH)in adverse pregnancy outcomes of severe preeclampsia.Methods Eighty cases of patients with hypertersive diseases of pregrancy who were hospitalized and delivered in Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University from December 2018 to January 2020 were selected as research objects and divided into severe preeclampsia group(n=34)and preeclampsia group(n=46),and 40 normal pregnant women in the same period were selected as control group.Serum MMP-9,PLGF and LDH indexes of pregnant women in the three groups were measured,pregnancy outcomes of pregnant women in the three groups were compared,and 34 patients with severe preeclampsia were divided into adverse pregnancy outcome group(n=10)and good pregnancy outcome group(n=24)according to pregnancy outcome.Basic data and serum MMP-9,PLGF and LDH indexes of patients in the two groups were compared.The predictive value of serum MMP-9,PLGF combined with LDH in adverse pregnancy outcome of severe preeclampsia was analyzed.ResultsThere were significant dfferences in maternal serum MMP-9,PLGF and LDH among the three groups(P<0.05).The incidence of adverse pregnancy outcome was 32.35%in severe preeclampsia group,8.70%in preeclampsia group and 2.50%in control group,and the difference was statistically significant(P<0.05).There were no significant differences in age and body mass index between the adverse pregnancy outcome group and the good pregnancy outcome group(P>0.05),there were significant differences in serum indexes of MMP-9,PLGF and LDH(P<0.05).Assign values to indicators with statistical differences in univariate analysis:MMP-9≤0.32 is 1,>0.32 is 0;PLGF≤0.80 is 1,>0.80 is 0;body mass index≥23.4 is 1,<23.4 is 0;LDH≥363.23 is 1,<363.23 is 0;age≥28 is 1 and age<28 is 0.MMP-9,PLCF and LDH were all influential factors leading to adverse pregnancy outcomes in patients with severe preeclampsia(P<0.05).Conclusion Maternal serum MMP-9 and PLGF can be used as predictive factors for adverse outcome of severe preeclampsia.MMP-9 and PLGF combined with LDH have higher predictive value for adverse pregnancy outcome of severe preeclampsia,which can provide reference for clinical diagnosis and treatment.
作者
胡睿
王鑫鑫
郑芳秀
Hu Rui;Wang Xinxin;Zheng Fangxiu(Department of Obstetrics and Gynecology,Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University,Xuzhou Jiangsu 221000,P.R.China;Prenatal Diagnostic Laboratory,Changzhou Maternal and Child Health Hospital Affiliated to Nanjing Medical University,Xuzhou Jiangsu 221000,P.R.China)
出处
《中国计划生育和妇产科》
2023年第2期80-84,共5页
Chinese Journal of Family Planning & Gynecotokology
