摘要
肥胖是由于脂肪细胞体积增大和数量增生而引起的脂肪组织异常或过度堆积导致的一种慢性代谢性疾病,由环境因素和遗传因素共同决定。近年来,自噬在调控脂肪细胞数量、脂肪生成和白色脂肪棕色化等过程中的作用引起了广泛关注。文章就脂肪组织中3种不同类型的自噬对脂肪生成、白色脂肪棕色化和脂肪代谢等过程的影响进行系统性总结回顾,旨在阐明自噬对脂肪组织功能及肥胖的影响,进而为肥胖的预防和治疗提供潜在靶点。
Obesity is a chronic metabolic disease characterized by abnormal or excessive accumulation of adipose tissue,which is caused by an increase in adipocyte volume(hypertrophy)and number(hyperplasia).It is determined by environmental factors and genetic factors.In recent years,the roles of autophagy in regulating adipocyte number,adipogenesis,and white fat browning process have attracted extensive attention.This article systematically reviewed the effects of three different types of autophagy in adipose tissue on processes such as adipogenesis,white fat browning,and fat metabolism,aiming to clarify the effect of autophagy on adipose tissue function and obesity,and then provide potential targets for obesity prevention and treatment.
作者
季学涛
张许
刘谨
李仲
JI Xuetao;ZHANG Xu;LIU Jin;LI Zhong(Key Laboratory of Rare Metabolic Disease,Department of Molecular Biology and Biochemistry,The Key Laboratory of Human Functional Genomics of Jiangsu Province,Nanjing Medical University,Nanjing 211166,China)
出处
《南京医科大学学报（自然科学版）》
CAS
北大核心
2023年第2期275-282,共8页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家自然科学基金(32130050,91957115)
南京医科大学科技发展基金面上项目(2016NJMU004)。
关键词
肥胖
脂肪组织
自噬
线粒体自噬
脂噬
obesity
adipose tissue
autophagy
mitophagy
lipophagy
