摘要
肝纤维化是各种慢性肝病的共同病理过程,与肝脏疾病进展相关,是影响肝脏疾病转归和肝细胞癌风险的关键因素。早期过程可逆,若不及时干预治疗,程度逐渐加重终将发展为肝硬化,甚至肝细胞癌,危及人们健康。因此,积极防治肝纤维化具有重要的意义,而肝纤维化的发病机制复杂,西医治疗单一、局限,尚缺乏疗效确切且公认的抗纤维化药物,治疗存在巨大的医疗需求。随着国内外学者的努力研究,中医药治疗成为了逆转肝纤维化和抗纤维化进展的热点和重要突破点,且发现了多靶点、多途径的优势,本文将从辩证、治法、药物配伍及与现代分子机制结合等方面详细阐述中医药治疗肝纤维化的特色和优势。
Hepatic fibrosis(HF) is the common pathological process of various chronic liver diseases and is associated with the progression of liver diseases,and it is also a key factor affecting the outcome of liver diseases and the risk of hepatocellular carcinoma(HCC).The early process of HF is reversible,but without timely intervention and treatment,HF may gradually aggravate and progress to liver cirrhosis and even HCC,which will endanger people’s health.Therefore,it is of great significance to actively prevent and treat HF;however,due to the complex pathogenesis of HF,Western medicine treatment is limited and there is still a lack of effective and widely accepted anti-fibrotic drugs,and thus there is a huge demand for medical treatment.With the efforts of scholars in China and globally,traditional Chinese medicine treatment has become a hotspot and a key breakthrough point in reversing HF and preventing its progression,with the advantages of multiple targets and pathways.This article elaborates on the advantages and characteristics of TCM treatment of HF from the aspects of syndrome differentiation,method of treatment,drug compatibility,and modern molecular mechanism.
作者
刘俊宏
李欣瑜
王淼蕾
符博雅
李林蔓
方慧
LIU Junhong;LI Xinyu;WANG Miaolei;FU Boya;LI Linman;FANG Hui(Department of Spleen and Stomach Diseases,The Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China;School of Integrated Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Gastroenterology,Zhang Ye People’s Hospital Affiliated to Hexi University,Zhangye,Gansu 734000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第2期267-272,共6页
Journal of Clinical Hepatology
基金
国家自然科学基金地区项目(81660773)
甘肃省组织部重点人才项目
甘肃省科学技术厅临床医学研究中心建设项目(21JR7RA682)。
关键词
中草药
肝纤维化
治疗学
医学
中国传统
Drugs,Chinese Herbal
Liver Fibrosis
Therapeutics
Medicine,Chinese Traditional
