摘要
产气荚膜梭菌(Clostridium perfringens,CP)是重要的食源性病原体之一,可对人类和动物健康造成严重威胁。CP在家禽中主要引起禽坏死性肠炎,严重影响了全球肉鸡贸易与生产。关于禽CP的研究当前主要集中于检测及分型方法、疫苗和耐药性方面。目前禽CP疫苗多处于实验室研发阶段,因此禽CP感染的防治主要依靠抗生素,而抗生素的频繁使用又导致了菌株耐药性问题,防治效果有限。因此,CP耐药性研究以及临床诊断技术完善及疫苗研发推进迫在眉睫。本文简述了CP的病原特点、致病机理及禽间的优势流行分型,梳理了禽CP不同检测方法的优点及分型方法,阐述了禽CP耐药现状以及疫苗研发方向及进展,提出了禽CP感染辅助防治措施,以期为CP感染防控提供参考。
Human and animal health could be seriously threatened by Clostridium perfringens(CP)that was one of major foodborne pathogens.Avian necrotizing enteritis was mainly caused by CP,damaging global trade and production of broilers.The methods of detection and typing,vaccines and drug resistance related to poultry CP were mainly researched.As current poultry CP vaccines were mostly under laboratory research,antibiotics were mainly used to prevent and control the infection,but bacterial resistance accompanied with their frequent use,which limited their effectiveness.Therefore,it was urgent to study the bacterial resistance,to improve clinical diagnostic techniques and to push forward vaccine development.In this paper,the pathogenic characteristics and mechanism of poultry CP,as well as dominant epidemic typing in poultry were reviewed.The advantages and typing of various detection methods of poultry CP were summarized,the status of bacterial resistance,the development and progress of vaccines were described,and auxiliary control measures were put forward for the purpose of providing a reference for the prevention and control of CP infection.
作者
杨文静
张富友
刘娜
王琳
王素春
潘俊慧
禹兰平
周凯钰太
张炜
田睿
梁晚枫
孙福亮
王楷宬
Yang Wenjing;Zhang Fuyou;Liu Na;Wang Lin;Wang Suchun;Pan Junhui;Yu Lanping;Zhou Kaiyutai;Zhang Wei;Tian Tui;Liang Wanfeng;Sun Fuliang;Wang Kaicheng(China Animal Health and Epidemiology Center,Qingdao,Shandong 266032,China;Yanbian University,Yanji,Jilin 133000,China;Key Laboratory of Animal Biosafety Risk Early Warning,Prevention and Control,Ministry of Agriculture and Rural Affairs(Southern China),Qingdao,Shandong 266032,China;Nanjing Agricultural University,Nanjing,Jiangsu 210095,China)
出处
《中国动物检疫》
CAS
2023年第3期46-53,共8页
China Animal Health Inspection
基金
中国动物卫生与流行病学中心创新基金项目(DW2021008)。
关键词
禽产气荚膜梭菌
流行病学
病原学
诊断技术
动物模型
poultry Clostridium perfringens
epidemiology
etiology
detection technique
animal model
