摘要
磷酸二酯酶8(PDE8)是环磷酸腺苷(cAMP)的特异性水解酶,包含PDE8A和PDE8B亚型,在机体多个组织器官表达,可通过调控cAMP水平发挥各种生物学作用,进而参与多种疾病的发生。本文就PDE8与痴呆、帕金森病、脑卒中、糖尿病、心功能不全、呼吸系统等多种疾病的关系进行总结研究,以期为以PDE8为靶点进行治疗药物的开发提供依据。
Phosphodiesterase8(PDE8)is a specific hydrolase of cyclic adenosine phosphate(cAMP),including PDE8A and PDE8B subtypes.It is expressed in many tissues and organs of the body and can play various biological roles by regulating the concentration of cAMP,so as to participate in the occurrence of a variety of diseases.In this paper,the research progress of the relationship between PDE8 and dementia,Parkinson's disease,stroke,diabetes,cardiac insufficiency,respiratory system and other diseases was reviewed,in order to provide a basis for the development of therapeutic drugs targeting PDE8.
作者
张猛
王丽宏
张芳芳
王浩
ZHANG Meng;WANG Lihong;ZHANG Fangfang;WANG Hao(Institute of Pharmacology,Shandong First Medical University,Tai'an 271016,China;Chaoyang Distric of the 968th Hospital of the People's Liberation Army,Chaoyang 122000,China)
出处
《老年医学研究》
2023年第1期50-54,共5页
Geriatrics Research
关键词
PDE8
痴呆
帕金森病
脑卒中
糖尿病
心功能不全
哮喘
慢性阻塞性肺疾病
肺纤维化
PDE8
dementia
Parkinson's disease
stroke
diabetes
cardiac insufficiency
asthma
chronic obstructive pulmonary disease
pulmonary fibrosis
