摘要
研究曲妥珠单抗靶向疗法对乳腺癌改良根治术后的近期疗效及生活质量的影响。选取2017年1月至2018年6月南方医科大学附属东莞医院收治的120例患者进行研究。按照简单随机分组法,分为对照组和观察组两组,各60例。对照组采用常规化疗方案治疗,观察组在常规化疗的基础上,给予曲妥珠单抗靶向治疗。随访3年,观察两组的治疗效果、国际生活质量评分(IQOLA)及并发症情况。观察组的总有效率为93.33%,显著高于对照组的73.33%,差异有统计学意义(P<0.05);治疗前,两组的各项IQOLA评分(健康状况、生理机能、社会功能、精神健康、躯体疾病)差异无统计学意义(P>0.05);治疗后,两组的各项IQOLA评分均明显升高,且观察组的健康状况、生理机能、社会功能、精神健康、躯体疾病评分均明显高于对照组,差异有统计学意义(P<0.05);观察组的并发症发生率为3.33%,显著低于对照组的20.00%,差异有统计学意义(P<0.05)。曲妥珠单抗靶向疗法对乳腺癌改良根治术后患者疗效显著,可明显提高患者的IQOLA评分,减少术后感染、皮瓣下积液、上肢淋巴水肿、皮瓣坏死的发生率,在临床中值得推广应用。
To analyze the short-term effect and quality of life of Trastuzumab targeted therapy for breast cancer after modified radical mastectomy, 120 cases patients from January 2017 to June 2018 in Dongguan Hospital Affiliated to Southern Medical University were randomly divided into two groups according to the simple random grouping method, including 60 in the control group and 60 in the observation group.The control group was treated with conventional chemotherapy, and the observation group was treated with Trastuzumab targeted therapy on the basis of the routine chemotherapy.After 3 years follow-up, the treatment effect, international quality of life score(IQOLA) and complications of the two groups were observed.The total effective rate of the observation group was 93.33%,which was significantly higher than 73.33% of the control group, the difference was statistically significant(P<0.05);Before treatment, there was no significant difference in IQOLA scores(health status, physiological function, social function, mental health and physical diseases) between the two groups(P>0.05);After treatment, the IQOLA scores of the two groups were significantly higher, and the health status, physiological function, social function, mental health and physical disease scores of the observation group were significantly higher than those of the control group, the difference was statistically significant(P<0.05);The incidence of complications in the observation group was 3.33%,which was significantly lower than 20.00% in the control group(P<0.05).Trastuzumab targeted therapy has a significant effect on modified radical mastectomy for breast cancer, which can significantly improve the IQOLA score and reduce the incidence of postoperative infection, skin flap accumulation, lymphedema and skin flap necrosis and is worthy of popularization and application in clinical practice.
作者
黄河清
王永霞
林伟强
叶娴
袁惠玲
HUANG He-qing;WANG Yong-xia;LIN Wei-qiang;YE Xian;YUAN Hui-ling(Breast Department of Dongguan Hospital Afiliated to Southern Medical University,Dongguan 523822,China)
出处
《药物生物技术》
CAS
2022年第6期594-597,共4页
Pharmaceutical Biotechnology
基金
国家自然科学基金项目(No.81802625)。
关键词
乳腺癌
改良根治术
曲妥珠单抗
靶向疗法
疗效
生活质量
并发症
Breast cancer
Modified radical operation
Trastuzumab
Targeted therapy
Efficacy
Quality of life
Complication
